Methods and compositions of DNA ligands for arthropod-borne pathogen detection and prophylaxis or therapy

ABSTRACT

Specific DNA ligand sequences for binding various arthropod-borne pathogens including arboviruses, rickettsia and parasites are described. Each of these sequences or their linear, two-and three-dimesional linked sequences can function in varying assay and sensor formats with varying degrees of success. Linkage of the whole or partial DNA sequences (putative binding sites) can be used to enhance specificity and affinity towards complex targets, thereby improving assay selectivity and sensitivity in many instances. In addition, the DNA sequences may bind and neutralize or prevent infection from arthropod-borne viruses, rickettsia and  Leishmania  or other parasites.

This application is based upon and claims priority from U.S. Provisional application Ser. No. 61/401,731 filed on Aug. 18, 2010, which is incorporated herein by reference.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention pertains to the field of nucleic acid (especially DNA) ligand-based diagnostics and prophylaxis or passive “immunity” (i.e., binding and blocking infectious agents from infecting or progressing throughout the body). In particular, the application relates to single-stranded deoxyribonucleic acid (“DNA”) and ribonucleic acid (“RNA”) ligand sequences, whether individual or linked together to form longer multiple binding site “receptors,” that specifically target and bind to arthropod-borne bacteria and viruses (arboviruses). Such arthropod-borne bacteria include the Rickettsia genus that can cause typhus or spotted fevers and deadly hemorrhagic fevers or other lethal diseases such as Crimean-Congo Hemorrhagic Fever (“CCHF”) viruses, Chikungunya (“CHIK”) viruses, Dengue viruses, and West Nile Viruses (“WNV”) or parasites such as various species of Leishmania . The arthropod vectors can include mosquitoes, ticks, lice, mites, midges, fleas, flies and sandflies.

These individual or linked DNA ligand (aptamer) sequences represent valuable target analyte-responsive components of diagnostic devices or biosensors. A biosensor can be defined as any device that employs a biologically-derived molecule as the sensing component and transduces a target analyte binding event into a detectable physical signal (including, but not limited to, changes in light intensity, absorbance, emission, wavelength, color, electrical conduction, electrical resistance, or other electrical properties, etc). Once bonded with the target, these DNA ligand sequences can be used to qualitatively determine the presence of target analyte, as well as to quantify the target analyte amount, in a sample using a broad variety of assay types and diagnostic or sensor platforms including, but not limited to: affinity-based lateral flow test strips, enzyme-linked (“ELISA-like”) microplate assays, membrane blotting, surface plasmon resonance (“SPR”), surface acoustic wave (“SAW”) or surface transverse wave (“STW”) sensors, magnetic bead (“MB”)-based capture, plastic-adherent sandwich assays, electrochemiluminescence (“ECL”), radioisotopic, fluorescence intensity assays including quantum dot (“QD”) or other fluorescent nanoparticle (“NP”)-based assays, fluorescence lifetime, and fluorescence polarization (“FP”) assays.

The invention includes general DNA ligand or aptamer-based methods of detection and quantification of these arthropod-borne diseases or related pathogens in homogenized or chemically (chaotrope or detergent)-extracted arthropods or animal or human body fluids such as whole blood, plasma, serum, sputum or saliva, interstitial, synovial, or cerebrospinal fluid aspirates, mucus, and urine or solid biopsy samples.

In addition, these DNA ligand sequences are valuable in competitive displacement assays which are not solely dependent on affinity or avidity to produce sensitive detection. Such assays would include competitive displacement fluorescence or Förster resonance energy transfer (“FRET”) assays or DNA ligand “beacon” FRET assays. Each of these types of assays and detection platforms has different applications in either central laboratories or as a component of portable detectors to identify infected arthropods (homogenates or extracts) or human or animal body fluids.

It has been established that aptamers can replace antibodies in lateral flow or chromatographic test strip assay formats and may enhance detection sensitivity by virtue of higher affinity versus comparable antibodies. Such test strips or dipsticks represent rapid, inexpensive and convenient visual detection formats. The user can add various human body fluids or arthropod homogenates or extracts (proteins removed from arthropod guts by low levels of detergents or chaotropes including guanidinium or metal salts) and obtain a positive or negative result by visualizing a red colloidal gold-aptamer conjugate line. Use of fluorescent nanoparticle (“FNP”)- or quantum dot (“QD”)-DNA aptamer conjugates on the test line of a lateral flow test strip in combination with a handheld UV penlight or common laser pointer to illuminate the fluorescent test and control lines appears to confer even greater sensitivity to the assay.

These individual or linked DNA ligand (concatamer-like aptamer) sequences represent valuable target analyte-responsive components of diagnostic devices or “biosensors.” A biosensor is defined as any sensor device that employs a biologically-derived molecule as the sensing component and transduces a target analyte binding event into a detectable physical signal, including, but not limited to, changes in light intensity, absorbance, transmittance, refraction (Surface Plasmon Resonance or SPR), wavelength, color, agglutination of cells or particles, fluorescence intensity, fluorescence lifetime, fluorescence polarization or anisotropy, fluorescence correlation spectroscopy (“FCS”), fluorescence or Förster resonance energy transfer (FRET; nonradiative dipole-dipole coupling of fluorophores or fluorophores and quenchers), upconverting phosphor (anti-Stokes shifts), two-photon interaction phenomena, Raman spectroscopy or surface-enhanced Raman spectroscopy (“SERS”), electrical conduction, electrical resistance or other electrical properties, mass, photon or radioactive particle emissions, etc.

Once bonded with the target, these DNA ligand sequences can be used to qualitatively determine the presence of analyte, as well as to quantify or semi-quantify the target analyte amount in a sample using a broad variety of assay types and diagnostic or sensor platforms including, but not limited to, affinity-based lateral flow test strips, membrane blotting, surface plasmon resonance (“SPR”), surface acoustic waveguides (“SAW”) or surface transverse waveguides (“STW”) devices, magnetic bead (“MB”)-based capture, plastic-adherent sandwich assays (“PASA”), chemiluminescence (“CL”), electrochemiluminescence (“ECL”), radioisotopic, fluorescence intensity, including quantum dot (“QD”) or other fluorescent nanoparticle (“FNP”) of dye-based, fluorescence lifetime, and fluorescence polarization (“FP”) assays, or enzyme-linked (“ELISA-like”) microplate assays.

Finally, since envelope- or capsid-protruding spike proteins on viral surfaces control binding to and invasion of host cells, the DNA ligands may have prophylactic or therapeutic value by simply binding or coating the viral spike proteins to prevent attachment to host cell surfaces and inhibiting virus entry into host cells. The prophylactic effect has been demonstrated for H5N1 influenza virus with similar DNA ligand or aptamer sequences that coated the H5N1 viruses and prevented or severely inhibited invasion of host cells and slowed or stopped subsequent viral replication.

2. Background Information

The DNA ligand sequences listed herein were derived by iterative cycles of affinity-based selection of DNA ligands from a randomized library using rickettsial or leishmanial surface molecules (cold 1.5M MgCl₂-extracted outer membrane proteins; OMPs), recombinant surface proteins or synthetic peptide epitopes derived from the known amino acid sequences of viral envelope protein spikes or other surface epitopes as defined in Table 1. After affinity-based selection, the DNA ligands were subjected to polymerase chain reaction (“PCR”) amplification followed by cloning and traditional Sanger dideoxynucleotide DNA sequencing. The utility of many of the sequences in ELISA-like plate assays as well as fluorescence (intensity) assays have been used and verified as illustrated by Tables 2-7 and FIGS. 2-7 and FIG. 9.

Some of the sequences function more effectively in affinity-based (ELISA-like, lateral flow strips, or fluorescence intensity) assays, while other DNA ligand sequences against the same pathogen targets have functioned better in competitive FRET assays). Therefore, all of the listed sequences have potential utility in some assay format for use in one or more tests or types of sensors for arthropod-borne pathogens and their therapy or prevention.

Arthropod-borne pathogens can present serious threats to human health in the form of alphaviruses or flaviviruses (arboviruses) that can cause encephalitis or hemorrhagic fevers or shock syndromes and death. Similarly, untreated rickettsial infections can lead to serious cases of spotted fevers or typhus with significant mortality. Finally, visceral and non-visceral leishmaniasis are serious conditions which are difficult to treat and can be fatal. All of these diseases are transferred to man by arthropod vectors (flying or other insects including mosquitoes, fleas, mites, midges, ticks, lice, flies and sandflies).

Rapid, accurate, and ultrasensitive detection of arthropod-borne diseases aids physicians by supplying key diagnostic information in the early phases of infection. This in turn allows administration of the proper antibiotic or anti-viral agent to treat these potentially deadly diseases before they become life-threatening. Current methods of detection such as lateral flow immunochromatographic test strips, although rapid, are not very sensitive and miss early stage disease detection or rely on detection of antibodies against the disease agent which may take weeks to emerge in the patient's serum. The same is true for many slower and more tedious ELISA tests which are somewhat more sensitive than lateral flow test strips, but often rely on detection of antibodies slowly made by the patient against the infectious pathogen over a period of weeks to months. In addition, there are no truly effective therapies for some of the arboviruses.

The DNA ligands disclosed herein can potentially and directly detect many arthropod-borne pathogenic microbes with greater sensitivity and speed than conventional antibodies. These same DNA ligands or aptamers may also have value as high affinity and highly specific binding agents against arboviruses, rickettsia and parasites to block or slow disease progression.

SUMMARY OF THE INVENTION

The present invention provides specific DNA sequence information for nucleic acid ligands selected and amplified from randomized pools to bind arthropod-borne pathogenic rickettsia, arboviruses and parasites in a variety of assay formats and sensor or diagnostic platforms. In addition, the DNA ligands may bind and slow or block infection and inhibit disease progression due to these pathogens, thereby functioning as prophylactics or therapeutics in vivo.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1A illustrates the general structure of an IgG antibody showing the linkage of hypervariable (HV) amino acid regions used for actual binding to target epitopes on complex antigens.

FIG. 1B illustrates nucleotide segments designed into the cDNA template.

FIG. 2 illustrates fluorescence spectra from titration of a plastic-adherent DNA ligand-magnetic bead and fluorescent nanoparticle assay.

FIG. 3 illustrates the results of screening a matrix of 5-biotinylated capture aptamer-magnetic beads and TYE 665 dye-5′-labeled reporter aptamers from the Crimean-Congo viral aptamer pool represented by SEQ ID NOs. 663-756.

FIG. 4 illustrates titration of CCHF viral peptides conjugated with 1% glutaraldehyde to bovine serum albumin.

FIG. 5 illustrates the specificity of the combination 22 CCHF plastic-adherent assay which detects gamma-irradiated CCHF viruses.

FIG. 6 illustrates similar plastic-adherent (PASA) DNA ligand-magnetic bead and DNA ligand-fluorescent nanoparticle sandwich assay fluorescence results.

FIG. 7 illustrates the plastic-adherent (PASA) sandwich assay results for three different combinations of capture and reporter DNA ligands for detection of Rickettsia typhi.

FIG. 8 illustrates the probe scheme used for the test and control lines on successful lateral flow nitrocellulose aptamer chromatographic test strips.

FIG. 9 shows several successful attempts to detect either gamma-irradiated viruses or purified BSA-glutaraldehyde-viral spike peptide conjugates on lateral flow strips.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

There is no single preferred embodiment for use of the DNA ligand sequences in assay or biosensor formats identified herein. Rather, as is the case with monoclonal antibodies, the sequences are useful to varying extents in a variety of assay formats and sensors or diagnostic devices chosen from the following non-comprehensive and non-exclusive list: lateral flow or chromatographic test strips or “dipsticks,” ELISA-like enzyme-linked microplate assays, magnetic bead-based capture assays, ECL or other chemiluminescence assays, radioisotopic assays and a variety of fluorescence assays including, but not limited to, fluorescence intensity or spectrofluorometry, lifetime, fluorescence polarization (“FP”) and fluorescence resonance energy transfer (“FRET”) assays (both end-labeled beacons and competitive FRET), SAW and STW-based detection, SPR.

Referring to the figures, FIG. 1A illustrates the general structure of an IgG antibody showing the linkage of hypervariable (“HV”) amino acid regions used for actual binding to target epitopes on complex antigens. Linear linkage of HV binding sites adds affinity, avidity and specificity to the antibody binding to complex targets. FIG. 1A is a Porter stick model of an antibody revealing the multiple hypervariable antigen combining or binding sites on both the heavy and light chains.

FIG. 1B illustrates the concept of linking aptamers or their binding sites in a linear fashion (although 2-D and 3-D dendrimer-like linkages are also possible) to mimic the linkage of multiple HV regions in antigen combining sites of antibody chains to enhance affinity, avidity, and specificity against complex target antigens (“Ag”) containing two or more distinct epitopes. The linked DNA ligands or aptamers are somewhat like concatamers, but can vary in the composition of DNA molecules that are linked together (i.e., can be non-repetitive versus repetitive concatamers). DNA ligands or aptamers or their shorter (5-10 base) binding sites can be linked during chemical or biochemical (enzymatic) synthesis to enhance aptamer binding affinity, avidity or specificity for improved assay sensitivity and selectivity.

As nature, immunology, and FIG. 1 suggest, the linkage of binding sites is beneficial in terms of enhancing receptor affinity, avidity (tensile binding strength), and selectivity versus complex targets with two or more distinct epitopes. This linkage can be sequential and linear (one-dimensional as in antibody heavy and light chain linkage of HV regions, FIG. 1A) or could be expanded into two or three dimensions much like DNA dendrimers or other more complex structures known to those skilled in the art. The linked DNA ligands or aptamers are somewhat like concatamers, but can vary in the composition of DNA molecules or subunits that are linked together (i.e., can be non-repetitive versus repetitive concatamers).

Linear linkage by chemical synthesis is quite facile, if one already knows the aptamer DNA sequences or shorter (approximately 5-10 base) binding site sequences to be linked. One can simply design one long sequence to incorporate the desired aptamers or binding sites with repetitive poly-adenine (A), poly-cytosine (C), poly-guanine (G), poly-thymine (T), poly-uridine (U), or other intervening sequences that are unlikely to bind the target epitopes. The length of the composite aptamer construct will be limited by current chemical synthesis technology to about 200 bases. However, cellular biosynthesis or enzymatic synthesis by polymerase chain reaction or asymmetric PCR (producing predominately single-stranded ss-DNA from a template) would not be so limited and should produce aptamer constructs up to 2,000 bases before the Taq polymerase or other thermostable DNA polymerase falls off the template DNA. The 2 kilobase Taq polymerase limit is the basis for the well-known Random Amplification of Polymorphic DNA (“RAPD”) method of DNA or genetic “fingerprint” analyses in which primers greater than 2 kilobases apart fail to produce a PCR product or amplicon, because Taq becomes disengaged from the template DNA before traveling 2,000 bases. In this way, lengthy aptamer constructs of less than 2 kilobases could be made from complementary DNA templates that would enable binding of different epitopes that are distal on the surface of relatively large objects such as viruses and whole bacteria, rickettsia, or eukaryotic parasites and other cells. Again, poly-A, C, G, T, or U or other linker nucleotide segments (similar to the concept of genetic “introns”) could be designed into the cDNA template to produce the resultant nascent strand to ligate aptamers or aptamer binding sites together into one contiguous linear chain with intervening linkers as shown in FIG. 1B.

For 2-D or 3-D linked aptamer structures a variety of linker chemistries are available, but the preferred embodiment is probably addition of a UniLink™ primary amine group somewhere in the mid-section of a larger multi-aptamer construct followed by covalent linkage and branching of two or more such multi-aptamer constructs by means of bifunctional linkers such as low levels (≦1%) of glutaraldehyde, carbodiimides, sulfo-EGS, sulfo-SMCC or other such bifunctional linkers familiar to those skilled in conjugate chemistry. This strategy would result in larger flower-like or dendrimer-like 2-D or 3-D structures consisting of two or more lengthy multi-aptamer structures.

FIG. 2 shows fluorescence spectra from titration of a plastic-adherent DNA ligand-magnetic bead and fluorescent nanoparticle assay for detection of gamma-irradiated (inactivated) Crimean-Congo Hemorrhagic Fever (CCHF) viruses. The spectra or curves each represent fluorescence intensity results as a function of wavelength elicited by interaction with various virus dilutions after collection on aptamer or DNA ligand-biotin-streptavidin-magnetic microbeads of 2.8 microns in diameter (Dynal brand from Invitrogen Corp.), exposure to red-emitting fluorescent nanoparticles (FNPs) or Fluospheres (Invitrogen, Inc.) and two washes in 1× binding buffer (1XBB; 0.5M NaCl, 10 mM Tris and 1 mM MgCl₂ at pH 7.6). Excitation was at 660 nm and the photomultiplier tube of the spectrofluorometer was set at 900 V. The spectra were obtained using DNA ligands for capture on magnetic beads and red fluorophore-labeled reporter DNA ligands selected from the pool of aptamers represented by SEQ ID NOs. 1-168. In particular, aptamer C1-1/7F (SEQ ID NO. 3) was used for gamma-irradiated viral capture on magnetic beads and 5′-amino aptamer C1-9F (SEQ ID NO. 15) was conjugated to red FNPs by means of a carbodiimide bond, purified and used as the reporter reagent. The clear detection of the 1; 6400 dilution above the background curve suggests detection of as few as 150 CCHF virus particles.

FIG. 3 shows the results of screening another matrix of 5-biotinylated capture aptamer-magnetic beads and TYE 665 dye-5′-labeled reporter aptamers from the Crimean-Congo (CCHF) viral aptamer pool represented by SEQ ID NOs. 663-756. The top 5 capture and reporter sandwich assay aptamer combinations were evaluated in all 25 (5 capture×5 reporter) possible combinations using a handheld Picofluor™ fluorometer set to its highest sensitivity (STD VAL=999.0). After washing in buffer on a permanent magnetic collection rack and reading this plastic-adherent assay in the polystyrene cuvettes, combination 22 (Gn6-25R; SEQ ID NO. 98) capture aptamer-biotin on streptavidin magnetic beads combined with E7A-18F; SEQ ID NO. 689) 5′-TYE 665-labeled reporter aptamer) was shown to be the strongest or most intense possible assay combination for further development.

FIG. 4 illustrates titration of CCHF viral peptides conjugated with 1% glutaraldehyde to bovine serum albumin (BSA) and purified by size-exclusion chromatography in the void volume of a Sephadex G25 column to emulate CCHF virus particles in pure phosphate buffered saline (PBS), a 50:50 PBS to human serum mix or 100% human serum matrix to test detection with the CCHF combination 22 assay using the Picofluor™ handheld fluorometer at its highest sensitivity setting. Clearly CCHF combination 22 detected the viral stimulant quite well in buffer and continued to detect the simulant even in pure human serum, albeit with less intense fluorescence output.

FIG. 5 shows the specificity of the combination 22 CCHF plastic-adherent assay which detects gamma-irradiated CCHF viruses of a comparable concentration much more intensely than unrelated Adenovirus, MS-2 bacteriophage, or Reovirus Type 3 Abney strain viruses.

FIG. 6 illustrates similar plastic-adherent (PASA) DNA ligand-magnetic bead and DNA ligand-fluorescent nanoparticle sandwich assay fluorescence results for the detection of Rickettsia conorii to a level of approximately 3 μL or 75 cells in some cases. Various DNA ligand sequences are used in capture and reporter roles in the four different experiments from the pool of SEQ ID NOs. 549-662.

FIG. 7 illustrates the plastic-adherent (PASA) sandwich assay results for three different combinations of capture and reporter DNA ligands for detection of Rickettsia typhi. Serial dilutions of the rickettsia were evaluated using a spectrofluorometer and red-emitting fluorescent nanoparticles. Again, these sandwich assay aptamer combinations were drawn from the pool of SEQ ID NOs. 549-662.

FIG. 8 illustrates the aptamer-5′-biotin-streptavidin-gold nanoparticle (GNP) or fluorescent nanoparticle (FNP) and streptavidin-biotin-5′-primer probe (to grab the complementary 18 base constant primer regions on the DNA ligand ends) scheme used for the test and control lines on successful lateral flow nitrocellulose aptamer chromatographic test strips displayed in FIG. 9 and described in the specifications or main text.

FIG. 9 documents several successful attempts to detect either gamma-irradiated viruses or purified BSA-glutaraldehyde-viral spike peptide conjugates on lateral flow strips using the method shown in FIG. 8. In particular, panel A shows a strong visible red spot indicating detection of the Chikungunya envelope peptide (ChE) with aptamer ChE 20R (SEQ ID NO. 204) and much fainter detection at the spot where ChE 17R aptamer was laid down and immobilized. Panel B shows similar positive red GNP detection spots for the C1-9F aptamer (SEQ ID NO. 15) detecting two different strains of actual gamma-irradiated CCHF virus, while the CCHF or C3-6R aptamer did not detect the viruses despite its strong performances and evidence of very high affinity in ELISA-like microplate assays and SPR analyses (Tables 2 and 3). Panel C illustrates two successful tests for West Nile Virus (WNV) envelope peptide-BSA conjugates using the WNV-18R and 19R aptamers which correspond to SEQ ID NOs. 306 and 307, respectively. Arrows in each of the panels point to the locations where capture dots or lines of DNA ligands were laid down.

TABLE 1 Targets for DNA Ligand Selection and Development Chikungunya (ChE) E1a Virus Surface Peptide (one letter amino acid-coded sequence) GDIQSRTPESKDVYANTQLVLQRPAVGTVHVPYSQAPSGFKYWLKERGAS Crimean-Congo Hemmorhagic Fever (CCHF) Virus Surface Peptide Targets (one-letter amino acid coded sequences) CCHF Peptide 1: RRLL CCHF Peptide 2: RKPL CCHF Peptide 3: GQGKTIEAYRAREG CCHF Peptide 4: GQGKTIEAYRAREGNAST GQGKTIEAYRAREG CCHF Altamura Gn 611: TQEGRGHVKLSRGSE CCHF 11E7-a: GLKFASLTCTGCYACSSGISCKVRIHVDEPDE CCHF 11E7-b: VAASSSLMARKLEFGTDSTFKAFSAMPKTSLCFYIV EREY CCHF 11E7-c: EDTQKCVNTKLEQPQSILIEHKGTIIGK Dengue Viruses

Recombinant Envelope Proteins Serotypes 1-4 from Virostat Corp., Portland, Me., Cat. Nos. 8812-8815.

Leishmania promastigotes

L. donovani, L. major WR2885 and other species of live cell surface cold (4° C.) overnight 1.5M MgCl₂-protein extracts obtained from the U.S. Army, Walter Reed Army Institute of Research (WRAIR).

Rickettsia

R. belli, R. conorii, R. parkeri, R. rickettsii, and R. typhi frozen cell protein extracts obtained from the U.S Navy Medical Research Command at WRAIR.

Tick-borne Encephalitis Viruses (TBEV)

Recombinant TBEV CE/gE from Feldan Bio Corp. (Boston, Mass. and Quebec, Canada) Cat. No. FB03-80-149.

West Nile Virus (WNV)

Recombinant Envelope Protein from GenWay Biotech Corp. San Diego, Calif., Cat. No. 10-511-248224.

EXAMPLE 1 ELISA-Like and SPR Affinity-Based Screening of Arthropod-Borne Pathogen DNA Ligands

Table 2 illustrates diversity of affinities for several different CCHF envelope peptide epitopes using two methods (0.1M bicarbonate buffer at pH 8.5 or N-oxy-succinimide-coated microwells) to immobilize the peptides and then carry out a traditional ELISA-like assay with 100 μL of 5′biotinylated DNA ligands for one hour at room temperature (RT, followed by a wash step, addition of 100 μL of 1:2,000 dilution of streptavidin-peroxidase (1 mg/mL stock) for 30 minutes at RT, three more wash steps and finally treatment with one-step ABTS substrate for 10 minutes at RT and reading of absorbance at 405 nm on a microplate reader. Tables 2 and 5-7 show ELISA-like rankings of the various top 3 to 10 DNA ligands by SEQ ID NOs for each of the general arthropod disease categories.

The highest ranking or highest affinity DNA ligands register the highest absorbance at 405 nm values and can be used in other types of affinity-based assays besides the ELISA-formatted assays. The highest affinity or highest ranking CCHF DNA ligands such as CCHF1-9F and CCHF3-6R also yielded very high affinity constants of greater 10⁸ to 4.23×10¹¹ by surface plasmon resonance (SPR) using a Biacore X-100 sensor as documented in Tables 3 and 4. The same or similar ELISA-like methods were used to screen and rank DNA ligand affinities against cognate arboviral, rickettsial and Leishmania targets as shown in Tables 5-7. Table 8 chronicles all of the actual candidate DNA ligand nucleotide sequences and corresponding SEQ ID NOs for all of the arthropod-borne pathogen-binding DNA ligands.

TABLE 2 ELISA-Like Rankings for Absorbance of Highest Affinity CCHF DNA Ligands NaHCO₃-Immobilized NOS-Immobilized Rank Abs 405 SEO ID NO. Aptamer Rank Abs 405 SEO ID NO. Aptamer 1 2.669 31 CCHF3-4F 1 2.219 15 CCHF1-9F 2 2.478 36 CCHF3-6R 2 2.141 36 CCHF3-6R 3 2.473 32 CCHF3-4R 3 2.048 4 CCHF1-1/7R 4 2.243 15 CCHF1-9F 4 1.987 32 CCHF3-4F 5 1.657 28 CCHF2-10R 5 1.987 16 CCHF1-9R 6 1.645 25 CCHF2-8F 6 1.987 2 CCHF1-1R 7 1.618 18 CCHF1-10R 7 1.949 14 CCHF1-6R 8 1.561 16 CCHF1-9R 8 1.903 3 CCHF1-1/7F 9 1.505 38 CCHF3-7R 9 1.853 7 CCHF1-3F 10  1.483 40 CCHF3-8R 10  1.848 25 CCHF2-8F

TABLE 3 Summary of CCHF DNA Ligand SPR Data CCHF DNA Ligand vs. Peptide K_(a) K_(d) (picoM) 1-9F Peptide 1 1.23 × 10⁸  8.13 1-9F Peptide 3 3.06 × 10⁶  327 1-9F Peptide 4  3.2 × 10¹⁰ 0.31 3-4R Peptide 3 8.85 × 10⁷  11.3 3-4R Peptide 4  3.1 × 10⁶  322 3-6R Peptide 3 4.23 × 10¹¹ 0.24 3-6R Peptide 4 2.19 × 10⁴  45,700

TABLE 4 Summary of Aptamer K_(A) Values vs. 11E7 CCHF Envelope Peptides by SPR DNA Ligands or CCHF Peptides Aptamers 11E7A 11E7B 11E7C E7A-11R 4.62 × 10⁸ 7.34 × 10⁷ 3.11 × 10⁹  Drosdov 4-7/10R 5.39 × 10⁹ 1.27 × 10⁷ Not done Drosdov 17R 2.09 × 10⁹ 6.08 × 10⁸ Not done E7B-14R  5.2 × 10⁸ 9.37 × 10⁷ 3.72 × 10⁷  Gn6-25R  5.5 × 10⁸ 2.07 × 10⁸ 1.48 × 10¹⁰ E7A-18F 1.39 × 10⁷ 3.48 × 10⁹ 1.92 × 10⁷ 

TABLE 5 ELISA-Like Rankings of Various Arthropod-borne Virus DNA Ligands SEQ ID Sequence NO. A 405 nm TBEV-2 R 760 2.601 TBEV-8 R 772 2.430 TBEV-2 F 759 2.314 TBEV-1 R 758 2.150 TBEV-4 R 764 2.124 TBEV-6 R 768 2.124 TBEV-6 F 767 2.067 TBEV-5 F 765 2.057 TBEV-7 F 769 2.021 TBEV-7 R 770 1.972 TBEV-10F 773 1.951 TBEV-1 F 757 1.935 TBEV-5 R 766 1.925 TBEV-3 R 762 1.908 TBEV-4 F 763 1.881 TBEV-8 F 771 1.847 TBEV-10R 774 1.823 TBEV-3 F 761 1.797 ChE - 16F 195 2.594 ChE - 20R 204 2.562 ChE - 17R 198 2.510 ChE - 19F 201 2.474 ChE - 16R 196 2.464 ChE - 19R 202 2.459 ChE - 17F 197 2.431 ChE - 18F 199 2.388 ChE - 20F 203 2.364 ChE - 18R 200 2.246 WNV 19F 307 2.727 WNV 18R 306 2.654 WNV 20F 309 2.538 WNV 20R 310 2.467 WNV 16F 303 2.450 WNV 16R 304 2.255 WNV 19R 308 2.177 WNV 18F 305 1.997

TABLE 6 ELISA-Like Rankings of Leishmania parasite DNA Ligands SEQ ID A 405 SEQ ID A 405 Sequence NO. nm Sequence NO. nm Lm 49,50R 548 2.501 Lm 29R 1.516 Lm 25R 516 2.406 Lm 34F 1.516 Lm 1147R 494 2.238 Lm 9R 1.504 Lm 610F 487 2.212 Lm 610R 1.466 Lm 16F 501 2.166 Lm 18R 1.446 Lm 19R 508 2.141 Lm 19F 1.442 Lm 17R 504 2.091 Lm 23R 1.442 Lm 3240F 525 2.045 Lm 16R 1.437 Lm 38F 535 1.979 Lm 45R 1.435 Lm 13R 496 1.935 Lm 35R 1.433 Lm 22R 1.916 Lm 32/40R 1.411 Lm 31R 1.899 Lm 17F 1.410 Lm 2643F 1.854 Lm 44F 1.391 Lm 241R 1.850 Lm 45F 1.380 Lm 241F 1.849 Lm 1F 1.378 Lm 46F 1.845 Lm 18F 1.367 Lm 34R 1.838 Lm 37F 1.366 Lm 42R 1.835 Lm 15F 1.365 Lm 4950F 1.806 Lm 35F 1.305 Lm 7F 1.791 Lm 1R 1.261 Lm 25F 1.787 Lm 21R 1.261 Lm 36R 1.709 Lm 5F 1.252 Lm 15R 1.698 Lm 39R 1.224 Lm 13F 1.684 Lm 9F 1.219 Lm 39F 1.679 Lm 4R 1.217 Lm 21F 1.659 Lm 1147F 1.216 Lm 38R 1.653 Lm 27R 1.207 Lm 23F 1.644 Lm 14F 1.182 Lm 46R 1.634 Lm 36F 1.181 Lm 2643R 1.626 Lm 3R 1.179 Lm 27F 1.598 Lm 44R 1.157 Lm 42F 1.596 Lm 29F 1.125 Lm 22F 1.576 Lm 4F 1.095 Lm 31F 1.569 Lm 3F 1.092 Lm 5R 1.537 Lm 37R 1.048 Lm 7R 1.516 Lm 14R 0.984

TABLE 7 ELISA-Like Rankings of Rickettisia DNA Ligands Avg. Absorbance Type Species Aptamer Clone SEQ ID NO. at 405 nm Whole Cell R. parkeri Rp-7R 556 1.33 Rp-14R 568 1.34 Rp-20F 577 1.37 R. rickettsii Rr-8/14/22R 584 1.21 Rr-17F 599 1.18 Rr-23R 610 1.22 R. typhi Rt-3R 620 1.48 Rt-5/16F 623 1.53 Rt-18R 648 1.45 OMPs R. belli R5-23F 317 2.93 R5-39F 347 1.95 R5-21bR 316 1.89 R. conorii R4-1R 352 2.12 R4-14R 362 2.05 R4-1F 351 1.99 R. parkeri R2-14F 393 2.08 R2-17R 400 2.05 R2-5F 379 1.95 R. rickettsii R3-39F 413 2.12 R3-39R 414 2.05 R3-40R 416 1.99 R. typhi R1-21R 426 2.88 R1-30R 444 2.85 R1-27bF 437 2.62

EXAMPLE 2 Ultrasensitive Detection of CCHF Virus and Rickettsia by Plastic-Adherent Sandwich Assay

The DNA ligand sequences have repeatedly been reduced to practice and used to detect low levels of CCHF viral envelope epitopes in neat buffer or animal sera as shown in FIG. 2. In this assay, two different CCHF sequences (CCHF 1-1/7F and 1-9F) from the SEQ ID NO. 3 and SEQ ID NO. 15 were 5′-biotin or 5′-amine modified upon synthesis and attached to either 10⁶ streptavidin-M280 (2.8 micron diameter) Dynal (Invitrogen, Inc.) MBs for virus capture or custom-made red-emitting carboxyl-coated FNPs (Invitrogen, Inc.) for reporting per test. The lower limit of detection (LLOD or 1:6400 dilution) for this assay was approximately 150 viral particles according to plaque assay data obtained from the U.S. Army at USAMRIID, Ft. Detrick, Md. Excitation was at 600 nm and the photomultiplier tube (“PMT”) was set at 900V.

Similarly sensitive plastic-adherent sandwich fluorescence assay results for two species of rickettsia cells with LLOD or about 75 cells are shown in FIGS. 5 and 6. These assays also sandwich rickettsial cells between magnetic bead-DNA ligand capture elements and DNA ligand-quantum dot or FNP-labeled reporter aptamers drawn from the SEQ ID NOs given in Table 8.

EXAMPLE 3 Lateral Flow (LF) Aptamer Sandwich Assays for Arthropod-Borne Bacteria or Viruses Using Colloidal Gold or Fluorescent Nanoparticles

Aptamer-based LF test strips are assembled much like traditional immunochromatographic strips by combining a Whatman GB002 sample pad, a Whatman Standard 17 conjugate pad, Millipore High Flow 240 analytical membrane (for slower migration and greatest sensitivity) and a Whatman 470 wicking or absorbent applied to a pressure sensitive sticky laminate backing. The sample pad is soaked in 0.05M Tris-HCl (pH 8.03) with 0.15 mM NaCl and 0.25% Triton X-100 for 30 minutes followed by air drying of the sample pad strip at 37° C. for several hours until completely dry. The components are assembled with the sample pad overlapping the conjugate pad and both the conjugate pad and wicking pads overlapping onto the nitrocellulose analytical membrane at each end of the analytical membrane as shown in FIG. 8. Thereafter, 4 mm wide strips are cut with a sharp paper cutter and laid into plastic cassettes for protection.

The streptavidin-colloidal gold for use in conjugates was obtained from DCN at 10 O.D. units per mL and 100 μL of this reagent was added to 100 μL of each 5′-biotinylated aptamer (1.3 to 1.5 mg/mL). Similarly, 100 μL of each 5′-biotin aptamer were added to 100 μL of simple streptavidin at (0.5 mL, Sigma Chemical Co.) and reagents were gently mixed at RT (20-25° C.) for 30 minutes. Any unbound aptamers were removed by use of sterile 30 kD molecular weight cut off spin columns which were centrifuged at 5,000×g for 10 minutes. The retentate was resuspended or rehydrated in 1004 of sterile 1 XBB and used in LF test strip experiments. The capture lines or “dots” (droplets) were laid down as 1 μL droplets a few millimeters from the conjugate pad on Millipore High Flow (HF) 240 nitrocellulose analytical membranes, sometimes in series, and air dried prior to baking in a UV oven for 15 minutes. The conjugate pads were loaded with 10-15 μL of colloidal gold-streptavidin-biotin-aptamer conjugates and target analytes were added in 100 μL of 1 XBB at the indicated amounts in each figure. All colloidal gold LF tests were conducted and evaluated after 5 minutes of run time to enable the HF 240 membranes time to fully develop. FIG. 9 specifically illustrates examples of successful lateral flow DNA ligand (aptamer) tests with the Chikungunya virus aptamer ChE 20R (SEQ ID NO. 204), Crimean-Congo (CCHF) virus aptamer C1-9F (SEQ ID NO. 15) and the West Nile virus (WNV) aptamers 18R and 19F (SEQ ID NOs. 306 and 307 respectively). Interestingly, some other aptamers used for the experiments represented in FIG. 9 such as ChE 17R and CCHF C3-6R which performed well in ELISA-like plate assays or SPR analysis for affinity assessment (Tables 2, 3, and 5), did not perform well in the lateral flow format, thereby further underscoring a basic tenet of this patent application that not all high-affinity DNA ligands from a given group will perform well in all assay formats.

DNA aptamer-quantum dot and aptamer-fluorescent nanoparticle (FluoSpheres™; “FS” from Invitrogen) conjugates were initially adhering rather tightly to glass fiber conjugate pads and not releasing well or not migrating as far as unconjugated particles, but these obstacles were overcome by switching to a larger porosity HighFlow (“HF”) 75 analytical membrane and 40 nm streptavidin-FS to obtain the successful proof-of-concept data shown in FIG. 9C.

Although the invention and DNA ligand sequences listed in Table 8 have been described with reference to specific embodiments, this description is not meant to be construed in a limited sense. Various modifications of the disclosed embodiments, as well as alternative embodiments of the inventions will become apparent to persons skilled in the art upon reference to the description of the invention. It is, therefore, contemplated that the appended claims will cover such modifications that fall within the scope of the invention.

TABLE 8 DNA Ligand Sequence ID Nos. Arthropod Aptamer Sequences 2011-Final <SEQ ID NO. 1 C1 - 1 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATAAAGAGCGGAACTTTTAGAACTGGATAGACTCATAGAGCAGGTGTGACGGAT <SEQ ID NO. 2 C1 - 1 R; DNA; Artificial> ATCCGTCACACCTGCTCTATGAGTCTATCCAGTTCTAAAAGTTCCGCTCTTTATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 3 C1 - 1/7 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAGTGTTGGGCCAATACGGTAACGTGTCCTTGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 4 C1 - 1/7 R; DNA; Artificial> ATCCGTCACACCTGCTCTCCAAGGACACGTTACCGTATTGGCCCAACACTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 5 C1 - 2 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTAACTTGTTGCTGATCTTATCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 6 C1 - 2 R; DNA; Artificial> ATCCGTCACACCTGCTCTGGATAAGATCAGCAACAAGTTAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 7 C1 - 3 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATGAGAGCAAAGATCCCAGGATACACTAATCCCTGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 8 C1 - 3 R; DNA; Artificial> ATCCGTCACACCTGCTCTACAGGGATTAGTGTATCCTGGGATCTTTGCTCTCATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 9 C1 - 4 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCTAGTGTTGAATCTGACCACAAGCTAAGTCTTCGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 10 C1 - 4 R; DNA; Artificial> ATCCGTCACACCTGCTCTCCGAAGACTTAGCTTGTGGTCAGATTCAACACTAGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 11 C1 - 5 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAGCACGGAAAGAGGGTCGCCTGATAGCCCGCCAATCAGAGCAGGTGTGACGGAT <SEQ ID NO. 12 C1 - 5 R; DNA; Artificial> ATCCGTCACACCTGCTCTGATTGGCGGGCTATCAGGCGACCCTCTTTCCGTGCTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 13 C1 - 6 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAGAAATGCCAACACAACGACACCGGTAGTGCTGCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 14 C1 - 6 R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGCAGCACTACCGGTGTCGTTGTGTTGGCATTTCTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 15 C1 - 9 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATGGTGACGGACCTTGAGAGCAAGACCGCTACGATTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 16 C1 - 9 R; DNA; Artificial> ATCCGTCACACCTGCTCTGAATCGTAGCGGTCTTGCTCTCAAGGTCCGTCACCATGGTGTTGGCTCCCGTAT <SEQ ID NO. 17 C1 - 10 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGAAGAACACTGCCTAGAATAAGTGGTGCAGGGCCGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 18 C1 - 10 R; DNA; Artificial> ATCCGTCACACCTGCTCTACGGCCCTGCACCACTTATTCTAGGCAGTGTTCTTCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 19 C2 - 4 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTAGGTGGTAGACTGTAGGTTACAGATAGCCGGGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 20 C2 - 4 R; DNA; Artificial> ATCCGTCACACCTGCTCTCCCCGGCTATCTGTAACCTACAGTCTACCACCTAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 21 C2 - 5 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCTGGCGCCGACCCTGTGGATTGCAGTCGCGGTTACAGAGCAGGTGTGACGGAT <SEQ ID NO. 22 C2 - 5 R; DNA; Artificial> ATCCGTCACACCTGCTCTGTAACCGCGACTGCAATCCACAGGGTCGGCGCCAGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 23 C2 - 6/9 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAGTGTTGGGCCAATACGGTAACGTGTCCTTGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 24 C2 - 6/9 R; DNA; Artificial> ATCCGTCACACCTGCTCTCCAAGGACACGTTACCGTATTGGCCCAACACTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 25 C2 - 8 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACAGACACCGAATGAGCAACACAACAACGGGACCCGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 26 C2 - 8 R; DNA; Artificial> ATCCGTCACACCTGCTCTACGGGTCCCGTTGTTGTGTTGCTCATTCGGTGTCTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 27 C2 - 10 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGTATCCGACCGGACACGGCACTACGACCTCTTTGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 28 C2 - 10 R; DNA; Artificial> ATCCGTCACACCTGCTCTGCAAAGAGGTCGTAGTGCCGTGTCCGGTCGGATACCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 29 C3 - 3 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGGTTGGTGTAAAGTGGCCAGCCCTTTACGCTAAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 30 C3 - 3 R; DNA; Artificial> ATCCGTCACACCTGCTCTACTTAGCGTAAAGGGCTGGCCACTTTACACCAACCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 31 C3 - 4 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACAGCTGACAATAGAAGGATATCCTGGGTACCGATGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 32 C3 - 4 R; DNA; Artificial> ATCCGTCACACCTGCTCTGCATCGGTACCCAGGATATCCTTCTATTGTCAGCTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 33 C3 - 5 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTGTGTATAACCCTAACGCTCTATGTTCGTTATGCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 34 C3 - 5 R; DNA; Artificial> ATCCGTCACACCTGCTCTTGCATAACGAACATAGAGCGTTAGGGTTATACACAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 35 C3 - 6 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCCCCCGCCTGGTTCCCGCAGGCCGCTCGCGTCCCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 36 C3 - 6 R; DNA; Artificial> ATCCGTCACACCTGCTCTCGGGACGCGAGCGGCCTGCGGGAACCAGGCGGGGGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 37 C3 - 7 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGGGCGTCACTAGCTCAGACCGTCCCCCGTTGGTATAGAGCAGGTGTGACGGAT <SEQ ID NO. 38 C3 - 7 R; DNA; Artificial> ATCCGTCACACCTGCTCTATACCAACGGGGGACGGTCTGAGCTAGTGACGCCCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 39 C3 - 8 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAGTGTTGGGCCAATACGGTGACGTGTCCTTGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 40 C3 - 8 R; DNA; Artificial> ATCCGTCACACCTGCTCTCCAAGGACACGTCACCGTATTGGCCCAACACTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 41 C3 - 9 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATGTCCTCGTTACAAGAATATTTCCTGTTACGCACCAGAGCAGGTGTGACGGAT <SEQ ID NO. 42 C3 - 9 R; DNA; Artificial> ATCCGTCACACCTGCTCTGGTGCGTAACAGGAAATATTCTTGTAACGAGGACATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 43 C4 - 7/10/20 F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAGTGTTGGGCCAATACGGTAACGTGTCCTTGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 44 C4 - 7/10/20 R; DNA; Artificial> ATCCGTCACACCTGCTCTCCAAGGACACGTTACCGTATTGGCCCAACACTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 45 Gn6 - 1F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAACTGAAAACTAAGACTTGGTTCCAAATCCTTTCTCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 46 Gn6 - 1R; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTAGAGAAAGGATTTGGAACCAAGTCTTAGTTTTCAGTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 47 Gn6 - 2F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGCCGGAGACTAGCCGAACCCTACTTTTTACTGTGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 48 Gn6 - 2R; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTACACAGTAAAAAGTAGGGTTCGGCTAGTCTCCGGCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 49 Gn6 - 4F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGTGCTGACTATACTATTCAAAAACAACACCCTAGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 50 Gn6 - 4R; DNA; Artificial> ATCCGTCACACCTGCTCTCCTAGGGTGTTGTTTTTGAATAGTATAGTCAGCACGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 51 Gn6 - 5F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGCCTTGTCTATTCTCTTAGTTTCCTGCTACTCCACAGAGCAGGTGTGACGGAT <SEQ ID NO. 52 Gn6 - 5R; DNA; Artificial> ATCCGTCACACCTGCTCTGTGGAGTAGCAGGAAACTAAGAGAATAGACAAGGCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 53 Gn6 - 6F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGATAGTTACCAGTCCCTTGTTAAAAATTTATATGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 54 Gn6 - 6R; DNA; Artificial> ATCCGTCACACCTGCTCTGCATATAAATTTTTAACAAGGGACTGGTAACTATCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 55 Gn6 - 7aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAGCTTTAGGTTACTTTTCAGACACTATATGTCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 56 Gn6 - 7aR; DNA; Artificial> ATCCGTCACACCTGCTCTGGGACATATAGTGTCTGAAAAGTAACCTAAAGCTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 57 Gn6 - 7bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATGCCCGCCTCGATAGAGACTGACCAGTATGTGAGAGCAGGTGTGACGGAT <SEQ ID NO. 58 Gn6 - 7bR; DNA; Artificial> ATCCGTCACACCTGCTCTCACATACTGGTCAGTCTCTATCGAGGCGGGCATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 59 Gn6 - 7cF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCTCATAGTTATGTAATAACGCTTATCTTGTCCGGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 60 Gn6 - 7cR; DNA; Artificial> ATCCGTCACACCTGCTCTGCCGGACAAGATAAGCGTTATTACATAACTATGAGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 61 Gn6 - 8F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCCATCTCAACCACCGTACCTCACTCGGCGACTTACAGAGCAGGTGTGACGGAT <SEQ ID NO. 62 Gn6 - 8R; DNA; Artificial> ATCCGTCACACCTGCTCTGTAAGTCGCCGAGTGAGGTACGGTGGTTGAGATGGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 63 Gn6 - 9F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGCTGTCCCCAAGACATTCAGTCTTTGCAACCCGGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 64 Gn6 - 9R; DNA; Artificial> ATCCGTCACACCTGCTCTACCGGGTTGCAAAGACTGAATGTCTTGGGGACAGCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 65 Gn6 - 10F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGCCATCCCCTTGACACTACCACTAAATCGGCGGTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 66 Gn6 - 10R; DNA; Artificial> ATCCGTCACACCTGCTCTGACCGCCGATTTAGTGGTAGTGTCAAGGGGATGGCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 67 Gn6 - 11F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATAGATGGATAAGGGGGAAACTGCCATTCGGTTAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 68 Gn6 - 11R; DNA; Artificial> ATCCGTCACACCTGCTCTACTAACCGAATGGCAGTTTCCCCCTTATCCATCTATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 69 Gn6 - 12F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTACCAGGACTAACTCGTTTTGCACTGGTCTCAGTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 70 Gn6 - 12R; DNA; Artificial> ATCCGTCACACCTGCTCTGACTGAGACCAGTGCAAAACGAGTTAGTCCTGGTAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 71 Gn6 - 13F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGGACGCGTACAGAGTTTATTCCTGAGATCCGTGCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 72 Gn6 - 13R; DNA; Artificial> ATCCGTCACACCTGCTCTAGCACGGATCTCAGGAATAAACTCTGTACGCGTCCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 73 Gn6 - 14F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGAAAAAAACAAACCCAAGGAATTACACCACAAAAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 74 Gn6 - 14R; DNA; Artificial> ATCCGTCACACCTGCTCTACTTTTGTGGTGTAATTCCTTGGGTTTGTTTTTTTCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 75 Gn6 - 15F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACATGTATTACACAGCTCGCATCTTCTTACCTGGCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 76 Gn6 - 15R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGCCAGGTAAGAAGATGCGAGCTGTGTAATACATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 77 Gn6 - 16aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCCTTTCCACCTACACTAGCTATCTTATCTCCTTATAGAGCAGGTGTGACGGAT <SEQ ID NO. 78 Gn6 - 16aR; DNA; Artificial> ATCCGTCACACCTGCTCTATAAGGAGATAAGATAGCTAGTGTAGGTGGAAAGGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 79 Gn6 - 16bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTAGGTTGGAATTTACATTCATGTTCTGTGGTCATAAGAGCAGGTGTGACGGAT <SEQ ID NO. 80 Gn6 - 16bR; DNA; Artificial> ATCCGTCACACCTGCTCTTATGACCACAGAACATGAATGTAAATTCCAACCTAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 81 Gn6 - 16cF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGAGCACACTAATCATGGCGGCCCGGCGCATCCCGACAGAGCAGGTGTGACGGAT <SEQ ID NO. 82 Gn6 - 16cR; DNA; Artificial> ATCCGTCACACCTGCTCTGTCGGGATGCGCCGGGCCGCCATGATTAGTGTGCTCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 83 Gn6 - 17F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAACTAGACAACCGCCCTTATACACACTGTACCAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 84 Gn6 17R; DNA; Artificial> ATCCGTCACACCTGCTCTACTGGTACAGTGTGTATAAGGGCGGTTGTCTAGTTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 85 Gn6 - 19F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCATCCCCGAATAAATAATGCTGCGCTGTTAAAGATAGAGCAGGTGTGACGGAT <SEQ ID NO. 86 Gn6 - 19R; DNA; Artificial> ATCCGTCACACCTGCTCTATCTTTAACAGCGCAGCATTATTTATTCGGGGATGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 87 Gn6 - 20F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAATTCCTCGTTGACCCCTAACTGTACTCTTAGCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 88 Gn6 - 20R; DNA; Artificial> ATCCGTCACACCTGCTCTGGCTAAGAGTACAGTTAGGGGTCAACGAGGAATTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 89 Gn6 - 21F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCCATTCTGAGACCCCCCGCGCATGTATTGGTCTTGAGAGCAGGTGTGACGGAT <SEQ ID NO. 90 Gn6 - 21R; DNA; Artificial> ATCCGTCACACCTGCTCTCAAGACCAATACATGCGCGGGGGGTCTCAGAATGGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 91 Gn6 - 22F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATGCTAGTGCCCCCACAGACGCACACTAAAGTATTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 92 Gn6 - 22R; DNA; Artificial> ATCCGTCACACCTGCTCTGGAATACTTTAGTGTGCGTCTGTGGGGGCACTAGCATGGTGTTGGCTCCCGTAT <SEQ ID NO. 93 Gn6 - 23F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGCCGTGCGCGCTCATTTTGAGAACCACTGCCCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 94 Gn6 - 23R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGGGCAGTGGTTCTCAAAATGAGCGCGCACGGCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 95 Gn6 - 24F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGTACTACCCACGGGCTTATTACCCCCTCATCCTTGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 96 Gn6 - 24R; DNA; Artificial> ATCCGTCACACCTGCTCTGCAAGGATGAGGGGGTAATAAGCCCGTGGGTAGTACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 97 Gn6 - 25F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTATGTTAACAAAGGCATACGGCAAGCTCTAACTGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 98 Gn6 - 25R; DNA; Artificial> ATCCGTCACACCTGCTCTACAGTTAGAGCTTGCCGTATGCCTTTGTTAACATAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 99 Gn6 - 27F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCTCAAGATAGCCGTTCATCCGACTGTCGCCATTGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 100 Gn6 - 27R; DNA; Artificial> ATCCGTCACACCTGCTCTACAATGGCGACAGTCGGATGAACGGCTATCTTGAGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 101 Gn6 - 28F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACATAATGGACAATCCCACTGGGCACGTTCTATAACCAGAGCAGGTGTGACGGAT <SEQ ID NO. 102 Gn6 - 28R; DNA; Artificial> ATCCGTCACACCTGCTCTGGTTATAGAACGTGCCCAGTGGGATTGTCCATTATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 103 Gn6 - 29F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAGCCCGAGCCCGCCGTTATATCCCATCGAGTTCCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 104 Gn6 - 29R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGGAACTCGATGGGATATAACGGCGGGCTCGGGCTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 105 Gn6 - 30F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCCCACCGAATATCCGCTTTCCTCGTCCTCCTTTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 106 Gn6 - 30R; DNA; Artificial> ATCCGTCACACCTGCTCTGAAAGGAGGACGAGGAAAGCGGATATTCGGTGGGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 107 E7c - 1aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATAGATGGATAAGGGGGAAACTGCCATTCGGTTAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 108 E7c - 1aR; DNA; Artificial> ATCCGTCACACCTGCTCTACTAACCGAATGGCAGTTTCCCCCTTATCCATCTATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 109 E7c - 1bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACATCTACGCCCAAGCCTCTATGTACAAGTAGCAACAAGAGCAGGTGTGACGGAT <SEQ ID NO. 110 E7c - 1bR; DNA; Artificial> ATCCGTCACACCTGCTCTTGTTGCTACTTGTACATAGAGGCTTGGGCGTAGATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 111 E7c - 2F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATCTCCACTGTGAACCTTATCGAGTTTTTTGTACGAGAGCAGGTGTGACGGAT <SEQ ID NO. 112 E7c - 2R; DNA; Artificial> ATCCGTCACACCTGCTCTCGTACAAAAAACTCGATAAGGTTCACAGTGGAGATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 113 E7c - 3F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAGGCTATACCGCGTTAGACTTTCTGAGTCGTCCTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 114 E7c - 3R; DNA; Artificial> ATCCGTCACACCTGCTCTGAGGACGACTCAGAAAGTCTAACGCGGTATAGCCTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 115 E7c - 4aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCACGCCCTTTTAGTGTCCAACTGAATCTTCACCTAAGAGCAGGTGTGACGGAT <SEQ ID NO. 116 E7c - 4aR; DNA; Artificial> ATCCGTCACACCTGCTCTTAGGTGAAGATTCAGTTGGACACTAAAAGGGCGTGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 117 E7c - 4bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATGCTTTTGGAGTATTTCGCCTCCAAGCTACTCCCCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 118 E7c - 4bR; DNA; Artificial> ATCCGTCACACCTGCTCTAGGGGAGTAGCTTGGAGGCGAAATACTCCAAAAGCATGGTGTTGGCTCCCGTAT <SEQ ID NO. 119 E7c - 5F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTGATCCTGCCGGTTCGCCCCTTGTTCCCACCTTTTAGAGCAGGTGTGACGGAT <SEQ ID NO. 120 E7c - 5R; DNA; Artificial> ATCCGTCACACCTGCTCTAAAAGGTGGGAACAAGGGGCGAACCGGCAGGATCAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 121 E7c - 6F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCACTGTTTAGGCACAACTTGCTTTCTTAGCCCCGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 122 E7c - 6R; DNA; Artificial> ATCCGTCACACCTGCTCTGCGGGGCTAAGAAAGCAAGTTGTGCCTAAACAGTGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 123 E7c - 7aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGCGTTTATTATGTTCCCCATGATTGCCACGGCTACAGAGCAGGTGTGACGGAT <SEQ ID NO. 124 E7c - 7aR; DNA; Artificial> ATCCGTCACACCTGCTCTGTAGCCGTGGCAATCATGGGGAACATAATAAACGCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 125 E7c - 7bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATATACTGCCGCAGTTTGGGCCCGCAGTCCATGGGCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 126 E7c - 7bR; DNA; Artificial> ATCCGTCACACCTGCTCTTGCCCATGGACTGCGGGCCCAAACTGCGGCAGTATATGGTGTTGGCTCCCGTAT <SEQ ID NO. 127 E7c - 8F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCTAAGTAATGCCAAAAACAACTCGGGTACGCAATGAGAGCAGGTGTGACGGAT <SEQ ID NO. 128 E7c - 8R; DNA; Artificial> ATCCGTCACACCTGCTCTCATTGCGTACCCGAGTTGTTTTTGGCATTACTTAGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 129 E7c - 9F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTTCTCTGTGACCAGTATACGTCCCATTTCCCTATTAGAGCAGGTGTGACGGAT <SEQ ID NO. 130 E7c - 9R; DNA; Artificial> ATCCGTCACACCTGCTCTAATAGGGAAATGGGACGTATACTGGTCACAGAGAAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 131 E7c - 10F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGATACGTTCCGTGCATGGATGTGCTGCCCCATGTTAGAGCAGGTGTGACGGAT <SEQ ID NO. 132 E7c - 10R; DNA; Artificial> ATCCGTCACACCTGCTCTAACATGGGGCAGCACATCCATGCACGGAACGTATCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 133 E7c - 11F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCATTTTCGTTTTTCTTGAGTATTTCGACCTTAGTGAGAGCAGGTGTGACGGAT <SEQ ID NO. 134 E7c - 11R; DNA; Artificial> ATCCGTCACACCTGCTCTCACTAAGGTCGAAATACTCAAGAAAAACGAAAATGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 135 E7c - 12F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTCGAAACCCATAATCTTTTCCTCACTCTGCGTATTAGAGCAGGTGTGACGGAT <SEQ ID NO. 136 E7c - 12R; DNA; Artificial> ATCCGTCACACCTGCTCTAATACGCAGAGTGAGGAAAAGATTATGGGTTTCGAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 137 E7c - 13F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGCATGGGGCTCTCCCTATTACGCAATCCGTTGTAGAGAGCAGGTGTGACGGAT <SEQ ID NO. 138 E7c - 13R; DNA; Artificial> ATCCGTCACACCTGCTCTCTACAACGGATTGCGTAATAGGGAGAGCCCCATGCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 139 E7c - 14F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCTTGTCCTCGGTCCGTCTTTGCATTCTGGTCTAAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 140 E7c - 14R; DNA; Artificial> ATCCGTCACACCTGCTCTTTTAGACCAGAATGCAAAGACGGACCGAGGACAAGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 141 E7c - 15F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCGCTGTAAGTGCTTGGGTCGACCGCGCCCGCTGCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 142 E7c - 15R; DNA; Artificial> ATCCGTCACACCTGCTCTGGCAGCGGGCGCGGTCGACCCAAGCACTTACAGCGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 143 E7C - 17F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGTGACGCAGGTGAGTCTGCCTCCCCATGTGCTCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 144 E7C - 17R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGAGCACATGGGGAGGCAGACTCACCTGCGTCACCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 145 E7C - 18R; DNA; Artificial> ATACGGGAGCCAACACCAATAGATGGATAAGGGGGAAACTGCCATTCGGTTAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 146 E7C - 18F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTACTAACCGAATGGCAGTTTCCCCCTTATCCATCTATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 147 E7C - 19F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTTCCGGGCTATACCGGGGCTCGCGCAATTCTGACCAGAGCAGGTGTGACGGAT <SEQ ID NO. 148 E7C - 19R; DNA; Artificial> ATCCGTCACACCTGCTCTGGTCAGAATTGCGCGAGCCCCGGTATAGCCCGGAAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 149 E7C - 20F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATAGATGGATAAGGGGGAAACTGCCATTCGGTTAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 150 E7C - 20R; DNA; Artificial> ATCCGTCACACCTGCTCTACTAACCGAATGGCAGTTTCCCCCTTATCCATCTATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 151 E7C - 21F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGTCTTTTATTCATCATGATCGCTGACCTACACCCCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 152 E7C - 21R; DNA; Artificial> ATCCGTCACACCTGCTCTTGGGGTGTAGGTCAGCGATCATGATGAATAAAAGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 153 E7C - 22F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTTCAAAAGTCAGATACAAAGACAGAGATTGGACTTAGAGCAGGTGTGACGGAT <SEQ ID NO. 154 E7C - 22R; DNA; Artificial> ATCCGTCACACCTGCTCTAAGTCCAATCTCTGTCTTTGTATCTGACTTTTGAAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 155 E7C - 23F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTATGTTAACAAAGGCATACGGCAAGCTCTAACTGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 156 E7C - 23R; DNA; Artificial> ATCCGTCACACCTGCTCTACAGTTAGAGCTTGCCGTATGCCTTTGTTAACATAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 157 E7C - 24F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAATATTACAATGCCAGAATCTACACATAATCCTATAGAGCAGGTGTGACGGAT <SEQ ID NO. 158 E7C - 24R; DNA; Artificial> ATCCGTCACACCTGCTCTATAGGATTATGTGTAGATTCTGGCATTGTAATATTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 159 E7C - 25F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTATGTTAACAAAGGCATACGGCAAGCTCTAACTGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 160 E7C - 25R; DNA; Artificial> ATCCGTCACACCTGCTCTACAGTTAGAGCTTGCCGTATGCCTTTGTTAACATAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 161 E7C - 26F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTTGACGCCGTGGCAACACGCTGACGAGCTTTACCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 162 E7C - 26R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGTAAAGCTCGTCAGCGTGTTGCCACGGCGTCAAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 163 E7C - 27F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCCAACTCACTATTACTTAGTAACCCTAACGATGGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 164 E7C - 27R; DNA; Artificial> ATCCGTCACACCTGCTCTGCCATCGTTAGGGTTACTAAGTAATAGTGAGTTGGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 165 E7C - 29F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATACGATCCAATGATGGACCCGTGCGGACTGATTTACAGAGCAGGTGTGACGGAT <SEQ ID NO. 166 E7C - 29F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTGTAAATCAGTCCGCACGGGTCCATCATTGGATCGTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 167 E7C - 30F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTCCATCTCCATGTAGCTAAAGTCGATACTCCATCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 168 E7C - 30R; DNA; Artificial> ATCCGTCACACCTGCTCTGGATGGAGTATCGACTTTAGCTACATGGAGATGGAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 169 ChE -1F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACACAGAGGACGGTTCGTCAGATGCCGTTTGCCACGAAGAGCAGGTGTGACGGAT <SEQ ID NO. 170 ChE -1F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTTCGTGGCAAACGGCATCTGACGAACCGTCCTCTGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 171 ChE 2F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAAAAAGGTCTTCTCCCACGATGTGTCCAATGCATCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 172 ChE - 2R; DNA; Artificial> ATCCGTCACACCTGCTCTGGATGCATTGGACACATCGTGGGAGAAGACCTTTTTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 173 ChE 3F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCGCCTCGACCGCTCGGGGCCCTTACCCTAGCTTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 174 ChE 3R; DNA; Artificial> ATCCGTCACACCTGCTCTGAAGCTAGGGTAAGGGCCCCGAGCGGTCGAGGCGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 175 ChE 4F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCACAACCGTAGGGACCCGCCTGGTCCCCAACCTAGAGAGCAGGTGTGACGGAT <SEQ ID NO. 176 ChE 4R; DNA; Artificial> ATCCGTCACACCTGCTCTCTAGGTTGGGGACCAGGCGGGTCCCTACGGTTGTGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 177 ChE 6F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCTCGGATGGTTATGATATAGTTTACAATCATGAAGAGAGCAGGTGTGACGGAT <SEQ ID NO. 178 ChE 6R; DNA; Artificial> ATCCGTCACACCTGCTCTCTTCATGATTGTAAACTATATCATAACCATCCGAGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 179 ChE 7F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACATAGCCAACCTCAGCCACACCGACTACGCTTGGCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 180 ChE 7R; DNA; Artificial> ATCCGTCACACCTGCTCTGGCCAAGCGTAGTCGGTGTGGCTGAGGTTGGCTATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 181 ChE 8F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTTATCTAATGGCAACTAGGGATAGTGAAAACTACCAGAGCAGGTGTGACGGAT <SEQ ID NO. 182 ChE 8R; DNA; Artificial> ATCCGTCACACCTGCTCTCCTCCTAGGAATGTAGTCGGGCGGATAAAGTGACAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 183 ChE 9F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTGTCACTTTATCCGCCCGACTACATTCCTAGGAGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 184 ChE 9R; DNA; Artificial> ATCCGTCACACCTGCTCTCCTCCTAGGAATGTAGTCGGGCGGATAAAGTGACAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 185 ChE 10F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCTTCGACGCCAACGACGAACGGCTTTGAAAGGCTAAGAGCAGGTGTGACGGAT <SEQ ID NO. 186 ChE 10R; DNA; Artificial> ATCCGTCACACCTGCTCTTAGCCTTTCAAAGCCGTTCGTCGTTGGCGTCGAAGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 187 ChE 11F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATGGAAGCCGTACCTTCACACCCGTTATTTAAAAACAGAGCAGGTGTGACGGAT <SEQ ID NO. 188 ChE 11R; DNA; Artificial> ATCCGTCACACCTGCTCTGTTTTTAAATAACGGGTGTGAAGGTACGGCTTCCATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 189 ChE 12F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGCTGGCCGGGAGGCCCGTCCAAGCCATTACCGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 190 ChE 12R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACGGTAATGGCTTGGACGGGCCTCCCGGCCAGCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 191 ChE 13F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACATATCACCGCACGCCTATTCCATGTGACGAATCTAAGAGCAGGTGTGACGGAT <SEQ ID NO. 192 ChE 13R; DNA; Artificial> ATCCGTCACACCTGCTCTTAGATTCGTCACATGGAATAGGCGTGCGGTGATATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 193 ChE 15F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGGCGGGCGGGGCATCTCGTGGGGGACGAAGGCGCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 194 ChE 15R; DNA; Artificial> ATCCGTCACACCTGCTCTTGCGCCTTCGTCCCCCACGAGATGCCCCGCCCGCCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 195 ChE 16F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCCTCCTGCGACGTCTGGAGAACAGCCTCTACTTTAAGAGCAGGTGTGACGGAT <SEQ ID NO. 196 ChE 16R; DNA; Artificial> ATCCGTCACACCTGCTCTTAAAGTAGAGGCTGTTCTCCAGACGTCGCAGGAGGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 197 ChE 17F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAAACCCGCACTACATCTCCTCTGCCCCCTTCTGATAAGAGCAGGTGTGACGGAT <SEQ ID NO. 198 ChE 17R; DNA; Artificial> ATCCGTCACACCTGCTCTTATCAGAAGGGGGCAGAGGAGATGTAGTGCGGGTTTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 199 ChE 18F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGTGGTCTTGTTTTGGATGTTTAGTGATGCGGGTTCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 200 ChE 18R; DNA; Artificial> ATCCGTCACACCTGCTCTAGAACCCGCATCACTAAACATCCAAAACAAGACCACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 201 ChE 19F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCTTTCGTGATAGCTATTAAGGCCTATTCGTATCGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 202 ChE 19R; DNA; Artificial> ATCCGTCACACCTGCTCTACGATACGAATAGGCCTTAATAGCTATCACGAAAGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 203 ChE 20F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATACTGAAGCCATACGTCTGTCCAACCGTCATAACTTAGAGCAGGTGTGACGGAT <SEQ ID NO. 204 ChE 20R; DNA; Artificial> ATCCGTCACACCTGCTCTAAGTTATGACGGTTGGACAGACGTATGGCTTCAGTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 205 D1-3F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCCTAAATTCCAGAGTGTACAAGAGAACGAACTACCAGAGCAGGTGTGACGGAT <SEQ ID NO. 206 D1-3R; DNA; Artificial> ATCCGTCACACCTGCTCTGGTAGTTCGTTCTCTTGTACACTCTGGAATTTAGGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 207 D1-4F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTACTCATATACCTTATACTATAAACAATCTGCGCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 208 D1-4R; DNA; Artificial> ATCCGTCACACCTGCTCTCGCGCAGATTGTTTATAGTATAAGGTATATGAGTAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 209 D1-5aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACATTCGTACTAGCCCCGGTTGCCCGTCGACCGGACAAGAGCAGGTGTGACGGAT <SEQ ID NO. 210 D1-5bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGAGGGCGCGCCTATTTCGCCAATTCGTCCGCAGCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 211 D1-5aR; DNA; Artificial> ATCCGTCACACCTGCTCTTGTCCGGTCGACGGGCAACCGGGGCTAGTACGAATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 212 D1-5bR; DNA; Artificial> ATCCGTCACACCTGCTCTCGCTGCGGACGAATTGGCGAAATAGGCGCGCCCTCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 213 D1-6F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACACATTATCGGCAACTGGCAAGGCTAAGGTACTGGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 214 D1-6R; DNA; Artificial> ATCCGTCACACCTGCTCTACCAGTACCTTAGCCTTGCCAGTTGCCGATAATGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 215 D1-8F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTGGCGACCCACTCCCCTGGTACGTCACCACAGCCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 216 D1-8R; DNA; Artificial> ATCCGTCACACCTGCTCTAGGCTGTGGTGACGTACCAGGGGAGTGGGTCGCCAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 217 D1-9F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAGACAACCGAGCTAATAGGCATTTCAACACCTGTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 218 D1-9R; DNA; Artificial> ATCCGTCACACCTGCTCTGGACAGGTGTTGAAATGCCTATTAGCTCGGTTGTCTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 219 D1-10F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGAAGACCATGTGAAGTAAAGACTTCAATTATCAGTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 220 D1-10R; DNA; Artificial> ATCCGTCACACCTGCTCTGACTGATAATTGAAGTCTTTACTTCACATGGTCTTCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 221 D2-2F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACAATAAATCCGTGCGCGTGACGCGTTTCATACAGTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 222 D2-2R; DNA; Artificial> ATCCGTCACACCTGCTCTGACTGTATGAAACGCGTCACGCGCACGGATTTATTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 223 D2-4F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTATTGGCTATACATTCGTTGTGAGAAACGCACCGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 224 D2-4R; DNA; Artificial> ATCCGTCACACCTGCTCTGCGGTGCGTTTCTCACAACGAATGTATAGCCAATAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 225 D2-5aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATGGGGACCAACTGTCCGGAGAGAGTCCTGTCGAGGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 226 D2-5bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACATAGACACAAGATATATCATATATTGCTCGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 227 D2-5bR; DNA; Artificial> ATCCGTCACACCTGCTCTCCCTCGACAGGACTCTCTCCGGACAGTTGGTCCCCATGGTGTTGGCTCCCGTAT <SEQ ID NO. 228 D2-5bR; DNA; Artificial> ATCCGTCACACCTGCTCTGCGAGCAATATATGATATATCTTGTGTCTATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 229 D2-6F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTGTAGCTGACAACTGTTTTACATGAACACTTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 230 D2-6R; DNA; Artificial> ATCCGTCACACCTGCTCTGAAGTGTTCATGTAAAACAGTTGTCAGCTACAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 231 D2-7F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGGTGCCAGCAGATTATAATTGAACAAACCAGCGATAGAGCAGGTGTGACGGAT <SEQ ID NO. 232 D2-7R; DNA; Artificial> ATCCGTCACACCTGCTCTATCGCTGGTTTGTTCAATTATAATCTGCTGGCACCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 233 D2-8F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCACATAGAAAAAAAATACAACCACATCGATTGACCAGAGCAGGTGTGACGGAT <SEQ ID NO. 234 D2-8R; DNA; Artificial> ATCCGTCACACCTGCTCTGGTCAATCGATGTGGTTGTATTTTTTTTCTATGTGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 235 D2-9F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAACCAGGTATTGTCCAAAATGGAAACAAATGAGGAATAGAGCAGGTGTGACGGAT <SEQ ID NO. 236 D2-9R; DNA; Artificial> ATCCGTCACACCTGCTCTATTCCTCATTTGTTTCCATTTTGGACAATACCTGGTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 237 D2-10F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACACACAAAAGGAATTGTATACTCGCATAAGGCCGCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 238 D2-10R; DNA; Artificial> ATCCGTCACACCTGCTCTGGCGGCCTTATGCGAGTATACAATTCCTTTTGTGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 239 D3-1F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGAAACGTGGACTGTGTAGGCAAACCTATTATTTTCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 240 D3-1R; DNA; Artificial> ATCCGTCACACCTGCTCTAGAAAATAATAGGTTTGCCTACACAGTCCACGTTTCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 241 D3-2F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCGCAATTGATGACTACCCTAAGAAATCTATTGGCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 242 D3-2R; DNA; Artificial> ATCCGTCACACCTGCTCTGGCCAATAGATTTCTTAGGGTAGTCATCAATTGCGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 243 D3-3aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGGCCGAGGTCCACTACCCCTATGGCTGGCCCTTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 244 D3-3bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCCTACGGGTGGATGATCCGCGGTGTTCGAGTGTTAGAGCAGGTGTGACGG <SEQ ID NO. 245 D3-3aR; DNA; Artificial> ATCCGTCACACCTGCTCTGGAAGGGCCAGCCATAGGGGTAGTGGACCTCGGCCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 246 D3-3bR; DNA; Artificial> CCGTCACACCTGCTCTAACACTCGAACACCGCGGATCATCCACCCGTAGGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 247 D3-4aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATGCAGTATCCACCTTCTCTTTTTTCTCACTCCACTGAGAGCAGGTGTGACGGAT <SEQ ID NO. 248 D3-4aR; DNA; Artificial> ATCCGTCACACCTGCTCTCAGTGGAGTGAGAAAAAAGAGAAGGTGGATACTGCATGGTGTTGGCTCCCGTAT <SEQ ID NO. 249 D3-4bF; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTCGAATGGGACAACTTCTCGATATCTACTATGGTTGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 250 D3-4bR; DNA; Artificial> ATACGGGAGCCAACACCACCAACCATAGTAGATATCGAGAAGTTGTCCCATTCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 251 D3-6F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGGATGGGTAAAGAAAGTCGCGAGACGATGATGCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 252 D3-6R; DNA; Artificial> ATCCGTCACACCTGCTCTGGCATCATCGTCTCGCGACTTTCTTTACCCATCCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 253 D3-9F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGACATCCGTTCTGAACACACGATAGTGATGATTGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 254 D3-9R; DNA; Artificial> ATCCGTCACACCTGCTCTACAATCATCACTATCGTGTGTTCAGAACGGATGTCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 255 D3-10F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGGTATTGTAAAGAAATGAAATCAGTAATATATTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 256 D3-10R; DNA; Artificial> ATCCGTCACACCTGCTCTGGAATATATTACTGATTTCATTTCTTTACAATACCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 257 D4-2F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATACAAAAATCCGAAGTTAAGACAGCTCACGCTTATCAGAGCAGGTGTGACGGAT <SEQ ID NO. 258 D4-2R; DNA; Artificial> ATCCGTCACACCTGCTCTGATAAGCGTGAGCTGTCTTAACTTCGGATTTTTGTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 259 D4-3F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATACATGGCAGCTCCTACAGATCACCACTCTAAGAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 260 D4-3R; DNA; Artificial> ATCCGTCACACCTGCTCTACTCTTAGAGTGGTGATCTGTAGGAGCTGCCATGTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 261 D4-4F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACAACTCACCAGGACACTCGGCCGCCCGGTCCCCAATAGAGCAGGTGTGACGGAT <SEQ ID NO. 262 D4-4R; DNA; Artificial> ATCCGTCACACCTGCTCTATTGGGGACCGGGCGGCCGAGTGTCCTGGTGAGTTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 263 D4-5F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGTTGACAACACATGACTCTACACGATATGTCACACAAGAGCAGGTGTGACGGAT <SEQ ID NO. 264 D4-5R; DNA; Artificial> ATCCGTCACACCTGCTCTTGTGTGACATATCGTGTAGAGTCATGTGTTGTCAACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 265 D4-6F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGCTATGAAGAAAGAAAAATGAGTAACACATAACGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 266 D4-6R; DNA; Artificial> ATCCGTCACACCTGCTCTGCGTTATGTGTTACTCATTTTTCTTTCTTCATAGCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 267 D4-7F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGCCCCCCCTCACTACTGTCCCGCCCCCCGCCGTGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 268 D4-7R; DNA; Artificial> ATCCGTCACACCTGCTCTCCACGGCGGGGGGCGGGACAGTAGTGAGGGGGGGCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 269 D4-9aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCGGCCAACGAAAGACCTCGCTCACTAGACACCCCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 270 D4-9bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCAGAAAATCAATATAACAACGTATGCTGGCTCCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 271 D4-9aR; DNA; Artificial> ATCCGTCACACCTGCTCTAGGGGTGTCTAGTGAGCGAGGTCTTTCGTTGGCCGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 272 D4-9bR; DNA; Artificial> ATCCGTCACACCTGCTCTCGGAGCCAGCATACGTTGTTATATTGATTTTCTGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 273 WNV -1F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATAGATGGATAAGGGGGAAACTGCCATTCGGTTAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 274 WNV -1R; DNA; Artificial> ATCCGTCACACCTGCTCTACTAACCGAATGGCAGTTTCCCCCTTATCCATCTATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 275 WNV - 2F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGATTGAAGCTCAAGCCTAAAGGTGACCAAAGGTAGAAGAGCAGGTGTGACGGAT <SEQ ID NO. 276 WNV 2R; DNA; Artificial> ATCCGTCACACCTGCTCTTCTACCTTTGGTCACCTTTAGGCTTGAGCTTCAATCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 277 WNV -3/7/11F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACAGGAGAGGCAGTAAAAGGGTTGGCTGCCTGGGTAGAGAGCAGGTGTGACGGAT <SEQ ID NO. 278 WNV 3/7/11R; DNA; Artificial> ATCCGTCACACCTGCTCTCTACCCAGGCAGCCAACCCTTTTACTGCCTCTCCTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 279 WNV 4aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTATTACTGAGCTGTGCGCCGCTACCTGCCTAGATTAGAGCAGGTGTGACGGAT <SEQ ID NO. 280 WNV 4aR; DNA; Artificial> ATCCGTCACACCTGCTCTAATCTAGGCAGGTAGCGGCGCACAGCTCAGTAATAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 281 WNV 4bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATGCGGGCTTCCTACTCCAACCCAGGACCTTCACCAGAGCAGGTGTGACGGAT <SEQ ID NO. 282 WNV 4bR; DNA; Artificial> ATCCGTCACACCTGCTCTGGTGAAGGTCCTGGGTTGGAGTAGGAAGCCCGCATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 283 WNV 5F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGCGGCTGTCTATGACCGGGCTTGTTGTTTCTGCTAAGAGCAGGTGTGACGGAT <SEQ ID NO. 284 WNV 5R; DNA; Artificial> ATCCGTCACACCTGCTCTTAGCAGAAACAACAAGCCCGGTCATAGACAGCCGCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 285 WNV 7F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACAGGAGAGGCAGTAAAAGGGTTGGCTGCCTGGGTAGAGAGCAGGTGTGACGGAT <SEQ ID NO. 286 WNV 7R; DNA; Artificial> ATCCGTCACACCTGCTCTCTACCCAGGCAGCCAACCCTTTTACTGCCTCTCCTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 287 WNV 8F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGAGGATTACAACTTTATGCGTGCAACCAGACACCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 288 WNV 8R; DNA; Artificial> ATCCGTCACACCTGCTCTTGGTGTCTGGTTGCACGCATAAAGTTGTAATCCTCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 289 WNV 9F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCTACAGATCCGCGAACCAGCCGACTACTCGTCCACAGAGCAGGTGTGACGGAT <SEQ ID NO. 290 WNV -9R; DNA; Artificial> ATCCGTCACACCTGCTCTGTGGACGAGTAGTCGGCTGGTTCGCGGATCTGTAGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 291 WNV 10F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACAGCTGATATTGGATGGTCCGGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 292 WNV 10R; DNA; Artificial> ATCCGTCACACCTGCTCTGCCGGACCATCCAATATCAGCTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 293 WNV 11F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACAGGAGAGGCAGTAAAAGGGTTGGCTGCCTGGGTAGAGAGCAGGTGTGACGGAT <SEQ ID NO. 294 WNV 11R; DNA; Artificial> ATCCGTCACACCTGCTCTCTACCCAGGCAGCCAACCCTTTTACTGCCTCTCCTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 295 WNV 12F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAGCTCTCACGTGACACAGTGCTCCGCCGTCAAAATGAGAGCAGGTGTGACGGAT <SEQ ID NO. 296 WNV 12R; DNA; Artificial> ATCCGTCACACCTGCTCTCATTTTGACGGCGGAGCACTGTGTCACGTGAGAGCTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 297 WNV 13F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCCCGCGCCCACTGCTTGTCACCTCTTAGCCCCCGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 298 WNV 13R; DNA; Artificial> ATCCGTCACACCTGCTCTGCGGGGGCTAAGAGGTGACAAGCAGTGGGCGCGGGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 299 WNV 14F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAACCCAATAAACTTATTGGACCTACGCTTTGATGATTAGAGCAGGTGTGACGGAT <SEQ ID NO. 300 WNV 14R; DNA; Artificial> ATCCGTCACACCTGCTCTAATCATCAAAGCGTAGGTCCAATAAGTTTATTGGGTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 301 WNV 15F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACACTGCATCCCTCTACCGTACTTACATTCCTGACATAGAGCAGGTGTGACGGAT <SEQ ID NO. 302 WNV 15R; DNA; Artificial> ATCCGTCACACCTGCTCTATGTCAGGAATGTAAGTACGGTAGAGGGATGCAGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 303 WNV 16F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATGTCAGGACCTCCATCGCCCGGGCCCGCCGCCGCTGAGAGCAGGTGTGACGGAT <SEQ ID NO. 304 WNV 16R; DNA; Artificial> ATCCGTCACACCTGCTCTCAGCGGCGGCGGGCCCGGGCGATGGAGGTCCTGACATGGTGTTGGCTCCCGTAT <SEQ ID NO. 305 WNV 18F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCCCGTCGCCAAGCACTTGGCTGGGCTCTAACGGCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 306 WNV 18R; DNA; Artificial> ATCCGTCACACCTGCTCTGGCCGTTAGAGCCCAGCCAAGTGCTTGGCGACGGGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 307 WNV 19F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACAGCTGATATCGGATGGTCCGGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 308 WNV 19R; DNA; Artificial> ATCCGTCACACCTGCTCTGCCGGACCATCCGATATCAGCTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 309 WNV 20F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCCGTGGCCTTCACCCAGCCAGGGGCCCCGTCTCTGAGAGCAGGTGTGACGGAT <SEQ ID NO. 310 WNV 20R; DNA; Artificial> ATCCGTCACACCTGCTCTCAGAGACGGGGCCCCTGGCTGGGTGAAGGCCACGGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 311 R; DNA; Artificial>B-5F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATGTCTCTTAGGATACAAAGCCAAACTGAGCCCGTGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 312 R; DNA; Artificial>B-5R; DNA; Artificial> ATCCGTCACACCTGCTCTGCACGGGCTCAGTTTGGCTTTGTATCCTAAGAGACATGGTGTTGGCTCCCGTAT <SEQ ID NO. 313 21aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGTCACAGTGTCTGGCCAGAATGCCAAGGGAATCGTTAGAGCAGGTGTGACGGAT <SEQ ID NO. 314 21aR; DNA; Artificial> ATCCGTCACACCTGCTCTAACGATTCCCTTGGCATTCTGGCCAGACACTGTGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 315 21bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAACACTAATACTAATGCCATTATGCGTGATCTATTTAGAGCAGGTGTGACGGAT <SEQ ID NO. 316 21bR; DNA; Artificial> ATCCGTCACACCTGCTCTAAATAGATCACGCATAATGGCATTAGTATTAGTGTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 317 23F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAACAAATAACCACCCTCAATGCTAGATAGTGGCTTAGAGCAGGTGTGACGGAT <SEQ ID NO. 318 23R; DNA; Artificial> ATCCGTCACACCTGCTCTAAGCCACTATCTAGCATTGAGGGTGGTTATTTGTTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 319 25F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCACTTACCCACCTATAAGGAATATTCTAGATCGGAAGAGCAGGTGTGACGGAT <SEQ ID NO. 320 25R; DNA; Artificial> ATCCGTCACACCTGCTCTTCCGATCTAGAATATTCCTTATAGGTGGGTAAGTGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 321 26F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCGGGCATTAACATGGAATATCCTTCCCCAGCGTCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 322 26R; DNA; Artificial> ATCCGTCACACCTGCTCTAGACGCTGGGGAAGGATATTCCATGTTAATGCCCGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 323 27F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGTCCACACTTGACCACAAAACATAATCCCATATTGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 324 27R; DNA; Artificial> ATCCGTCACACCTGCTCTACAATATGGGATTATGTTTTGTGGTCAAGTGTGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 325 28F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAAGATAGTAAAGCTAGAGACATCTCAGAGCAGGAGAGAGCAGGTGTGACGGAT <SEQ ID NO. 326 28R; DNA; Artificial> ATCCGTCACACCTGCTCTCTCCTGCTCTGAGATGTCTCTAGCTTTACTATCTTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 327 29F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAAGGCAACAGTCTCTTCCTACTATTAAAACGAAACGAGAGCAGGTGTGACGGAT <SEQ ID NO. 328 29R; DNA; Artificial> ATCCGTCACACCTGCTCTCGTTTCGTTTTAATAGTAGGAAGAGACTGTTGCCTTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 329 30F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCGTCATAATATTCCTGTTGTGGCCCTATTGGACGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 330 30R; DNA; Artificial> ATCCGTCACACCTGCTCTCCGTCCAATAGGGCCACAACAGGAATATTATGACGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 331 31F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAATATCTAACCATACATTTATACAAGTGGTTCATAGAGAGCAGGTGTGACGGAT <SEQ ID NO. 332 31R; DNA; Artificial> ATCCGTCACACCTGCTCTCTATGAACCACTTGTATAAATGTATGGTTAGATATTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 333 32F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACAAGTTCAACGAGTTGATAACACAACATGACCGCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 334 32R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGCGGTCATGTTGTGTTATCAACTCGTTGAACTTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 335 33F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTAATAAAAATGAAAAACACCCCTCAACACCCATGAGAGCAGGTGTGACGGAT <SEQ ID NO. 336 33R; DNA; Artificial> ATCCGTCACACCTGCTCTCATGGGTGTTGAGGGGTGTTTTTCATTTTTATTAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 337 34F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACATTGAGCGTAAGCACCACGCCTTCTAGGTCGAGCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 338 34R; DNA; Artificial> ATCCGTCACACCTGCTCTAGCTCGACCTAGAAGGCGTGGTGCTTACGCTCAATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 339 35F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAGTCGTTCTGACATGTACTTTTGAGGAAATGGTGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 340 35; DNA; Artificial>R ATCCGTCACACCTGCTCTGCACCATTTCCTCAAAAGTACATGTCAGAACGACTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 341 36F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTACTCGCTCTGTATGCGCCTCCCACCCTCTGATAGAGAGCAGGTGTGACGGAT <SEQ ID NO. 342 36R; DNA; Artificial> ATCCGTCACACCTGCTCTCTATCAGAGGGTGGGAGGCGCATACAGAGCGAGTAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 343 37F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGAGTCGGCTACAGAGGTCTGATGTTAAAGCGATGGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 344 37R; DNA; Artificial> ATCCGTCACACCTGCTCTACCATCGCTTTAACATCAGACCTCTGTAGCCGACTCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 345 38F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACACCATTCTGGCCCCCTCCCCTTCACCGATCCTCTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 346 38R; DNA; Artificial> ATCCGTCACACCTGCTCTGAGAGGATCGGTGAAGGGGAGGGGGCCAGAATGGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 347 39F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCACTGCAGTTAACATTTACGAAGAGGCTTTAATGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 348 39R; DNA; Artificial> ATCCGTCACACCTGCTCTGCATTAAAGCCTCTTCGTAAATGTTAACTGCAGTGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 349 40F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAACCCGGCGTTATATCACCTCATGGAGAAAAGTGCGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 350 40R; DNA; Artificial> ATCCGTCACACCTGCTCTACGCACTTTTCTCCATGAGGTGATATAACGCCGGGTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 351 1F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCACAACTTAAGTGCAAGCAAATTCGGATTAACCAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 352 1R; DNA; Artificial> ATCCGTCACACCTGCTCTTTGGTTAATCCGAATTTGCTTGCACTTAAGTTGTGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 353 4F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGACTACATTGTGTTCAAGCGCCGAAGACGCTATCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 354 4R; DNA; Artificial> ATCCGTCACACCTGCTCTTGATAGCGTCTTCGGCGCTTGAACACAATGTAGTCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 355 8F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCATACCAGCAACGGAAGCTGCCCAAAGAATTTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 356 8R; DNA; Artificial> ATCCGTCACACCTGCTCTGAAATTCTTTGGGCAGCTTCCGTTGCTGGTATGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 357 9F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATGCTAAATACCGATGCTTTTCAATGTGATGGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 358 9R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACCATCACATTGAAAAGCATCGGTATTTAGCATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 359 12F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCCGGGCCATGGTAGAGTGTTATAATCGAACAAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 360 12R; DNA; Artificial> ATCCGTCACACCTGCTCTTTTGTTCGATTATAACACTCTACCATGGCCCGGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 361 14F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAGTCCAAGCCAAACAAGAGCATAACACCAAATCTGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 362 14R; DNA; Artificial> ATCCGTCACACCTGCTCTCCAGATTTGGTGTTATGCTCTTGTTTGGCTTGGACTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 363 17F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATGCTAAATACCGATGCTTTTCAATGTGATGGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 364 17R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACCATCACATTGAAAAGCATCGGTATTTAGCATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 365 18F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACATAGCTACTACAGAACTCAGGGCTAAAGTCTTATAGAGCAGGTGTGACGGAT <SEQ ID NO. 366 18R; DNA; Artificial> ATCCGTCACACCTGCTCTATAAGACTTTAGCCCTGAGTTCTGTAGTAGCTATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 367 19F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCATACCAGCAACGGAAGCTGCCCAAAGAATTTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 368 19R; DNA; Artificial> ATCCGTCACACCTGCTCTGAAATTCTTTGGGCAGCTTCCGTTGCTGGTATGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 369 20F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGATCGATATATGACACCAGGTACACCACAGACTTGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 370 20R; DNA; Artificial> ATCCGTCACACCTGCTCTGCAAGTCTGTGGTGTACCTGGTGTCATATATCGATCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 371 1F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCTACTCGAACATCTTAAAAGCAGTCTAAGCAAACTAGAGCAGGTGTGACGGAT <SEQ ID NO. 372 1R; DNA; Artificial> ATCCGTCACACCTGCTCTAGTTTGCTTAGACTGCTTTTAAGATGTTCGAGTAGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 373 3aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAGATCTTTTACGAACACCGCCGAAGATTATCATTTAGAGCAGGTGTGACGGAT <SEQ ID NO. 374 3aR; DNA; Artificial> ATCCGTCACACCTGCTCTAAATGATAATCTTCGGCGGTGTTCGTAAAAGATCTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 375 3bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAATGATGAATAGGCAACTTGCGGTGCCACGATCTTGAGAGCAGGTGTGACGGAT <SEQ ID NO. 376 3bR; DNA; Artificial> ATCCGTCACACCTGCTCTCAAGATCGTGGCACCGCAAGTTGCCTATTCATCATTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 377 4F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCGGCCGAATAGATATAATTCACAAAGAGTGTCCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 378 4R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGGACACTCTTTGTGAATTATATCTATTCGGCCGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 379 5F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGAAAATGAATACTTCCCAAGCTTGTCAAGCAAGTAAGAGCAGGTGTGACGGAT <SEQ ID NO. 380 5R; DNA; Artificial> ATCCGTCACACCTGCTCTTACTTGCTTGACAAGCTTGGGAAGTATTCATTTTCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 381 6F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAACAGGCTGAGTGTACTGCTACCTTGCAGTATCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 382 6R; DNA; Artificial> ATCCGTCACACCTGCTCTTGATACTGCAAGGTAGCAGTACACTCAGCCTGTTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 383 9F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGATTTTCCAGCAAATCCAGTCCCTATATGTGCTTGAAGAGCAGGTGTGACGGAT <SEQ ID NO. 384 9R; DNA; Artificial> ATCCGTCACACCTGCTCTTCAAGCACATATAGGGACTGGATTTGCTGGAAAATCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 385 10F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAACAACCACCAGTCAAGACCCAACGCGTGGCGAGGAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 386 10R; DNA; Artificial> ATCCGTCACACCTGCTCTTTCCTCGCCACGCGTTGGGTCTTGACTGGTGGTTGTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 387 11F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGGATATGCTGAATATGCATTGTCACGCTGAAGTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 388 11R; DNA; Artificial> ATCCGTCACACCTGCTCTGACTTCAGCGTGACAATGCATATTCAGCATATCCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 389 12F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATACAACAAGTCAAAAAGAAATAGAAAGTTGAACGAGAGCAGGTGTGACGGAT <SEQ ID NO. 390 12R; DNA; Artificial> ATCCGTCACACCTGCTCTCGTTCAACTTTCTATTTCTTTTTGACTTGTTGTATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 391 13F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAACAGACGTTTGGGGCAATGATATAAAGTTAATCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 392 13R; DNA; Artificial> ATCCGTCACACCTGCTCTTGATTAACTTTATATCATTGCCCCAAACGTCTGTTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 393 14F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAACGGTTCCCTTAATGCGCTACCCACACTATACAAGAGCAGGTGTGACGGAT <SEQ ID NO. 394 14R; DNA; Artificial> ATCCGTCACACCTGCTCTTGTATAGTGTGGGTAGCGCATTAAGGGAACCGTTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 395 15F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCGCTGCCTGTATGGCAGACCTACCTGACCCTCTTTAGAGCAGGTGTGACGGAT <SEQ ID NO. 396 15R; DNA; Artificial> ATCCGTCACACCTGCTCTAAAGAGGGTCAGGTAGGTCTGCCATACAGGCAGCGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 397 16F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAGATGCGAGCCAATAGTGTCACAATAATTGTCCGAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 398 16R; DNA; Artificial> ATCCGTCACACCTGCTCTTTCGGACAATTATTGTGACACTATTGGCTCGCATCTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 399 17F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAGATATAGACTCTAATTGATTACCATTCATAGGAAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 400 17R; DNA; Artificial> ATCCGTCACACCTGCTCTTTTCCTATGAATGGTAATCAATTAGAGTCTATATCTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 401 18F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCCAGTTCCAATTACGCGTAGATAGTCACAATCCAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 402 18R; DNA; Artificial> ATCCGTCACACCTGCTCTTTGGATTGTGACTATCTACGCGTAATTGGAACTGGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 403 19F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTTACCTCCCCTACCACACCTCCAACTAAAACCTGAAGAGCAGGTGTGACGGAT <SEQ ID NO. 404 19R; DNA; Artificial> ATCCGTCACACCTGCTCTTCAGGTTTTAGTTGGAGGTGTGGTAGGGGAGGTAAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 405 20F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGATCAAACCACTTGCCGTCAAGGCAATGGCCCCTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 406 20R; DNA; Artificial> ATCCGTCACACCTGCTCTGAGGGGCCATTGCCTTGACGGCAAGTGGTTTGATCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 407 31F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCCGTTTTTGATCTAATGAGGATACAATATTCGTCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 408 31R; DNA; Artificial> ATCCGTCACACCTGCTCTAGACGAATATTGTATCCTCATTAGATCAAAAACGGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 409 36F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCCCTCCGGACCCACCCCTGATGCCACGTGCCCCTGAGAGCAGGTGTGACGGAT <SEQ ID NO. 410 36R; DNA; Artificial> ATCCGTCACACCTGCTCTCAGGGGCACGTGGCATCAGGGGTGGGTCCGGAGGGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 411 37F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGACCCTGCCCCAGCCCCTTAGCCCCGGCGCGCGACGAGAGCAGGTGTGACGGAT <SEQ ID NO. 412 37R; DNA; Artificial> ATCCGTCACACCTGCTCTCGTCGCGCGCCGGGGCTAAGGGGCTGGGGCAGGGTCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 413 39F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACACACAGAGCGCCATGGACTCAGTCAGATGTGATGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 414 39R; DNA; Artificial> ATCCGTCACACCTGCTCTACATCACATCTGACTGAGTCCATGGCGCTCTGTGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 415 40F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGGCACGAAGACGAGGTGAAAAGTCAGCTTAGTGAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 416 40R; DNA; Artificial> ATCCGTCACACCTGCTCTTTCACTAAGCTGACTTTTCACCTCGTCTTCGTGCCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 417 41F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACACCCCATGAGATCACCATTCACTCGCACCCCCACGAGAGCAGGTGTGACGGAT <SEQ ID NO. 418 41R; DNA; Artificial> ATCCGTCACACCTGCTCTCGTGGGGGTGCGAGTGAATGGTGATCTCATGGGGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 419 43F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGGCTATTTGTTAGCGCTCTCTAGTTCCACATGACCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 420 43R; DNA; Artificial> ATCCGTCACACCTGCTCTTGGTCATGTGGAACTAGAGAGCGCTAACAAATAGCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 421 44F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATGGCTGGTACACTCCCGGTTCCCTGCCGTTGAGCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 422 44R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGCTCAACGGCAGGGAACCGGGAGTGTACCAGCCATGGTGTTGGCTCCCGTAT <SEQ ID NO. 423 45F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGGGGTGGGTCGAACCCTTGTCTGGGAGGTGCTTCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 424 45R; DNA; Artificial> ATCCGTCACACCTGCTCTAGAAGCACCTCCCAGACAAGGGTTCGACCCACCCCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 425 21F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATCTTACTAGTTTGGGAAAAAAATTAAATATAAGCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 426 21R; DNA; Artificial> ATCCGTCACACCTGCTCTTGCTTATATTTAATTTTTTTCCCAAACTAGTAAGATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 427 22F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATTATCCACTGATAACGAAAAGATCTGGACAGTTGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 428 22R; DNA; Artificial> ATCCGTCACACCTGCTCTACAACTGTCCAGATCTTTTCGTTATCAGTGGATAATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 429 24F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGTTGACTTAGGGTCAAACTATGGACACTCACCCGTAAGAGCAGGTGTGACGGAT <SEQ ID NO. 430 24R; DNA; Artificial> ATCCGTCACACCTGCTCTTACGGGTGAGTGTCCATAGTTTGACCCTAAGTCAACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 431 25F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTACTAGACATCGTAGCCCGACGTCCGTGGATTGGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 432 25R; DNA; Artificial> ATCCGTCACACCTGCTCTCCCAATCCACGGACGTCGGGCTACGATGTCTAGTAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 433 26F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGATATACCGTAACATTAATAGACAAGTTAAATACCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 434 26R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGTATTTAACTTGTCTATTAATGTTACGGTATATCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 435 27aF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAACATAGTGCTCGCATCCTATGGCGTAACGAGACTACAGAGCAGGTGTGACGGAT <SEQ ID NO. 436 27aR; DNA; Artificial> ATCCGTCACACCTGCTCTGTAGTCTCGTTACGCCATAGGATGCGAGCACTATGTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 437 27bF; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCAACGAATACTACCAGGCCTAGCACAATACACAACAGAGCAGGTGTGACGGAT <SEQ ID NO. 438 27bR; DNA; Artificial> ATCCGTCACACCTGCTCTGTTGTGTATTGTGCTAGGCCTGGTAGTATTCGTTGTTGGCTCCCGTAT <SEQ ID NO. 439 28F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTAGAAAAGACATCGCTAAATGACGGGCACGAATGAGAGCAGGTGTGACGGAT <SEQ ID NO. 440 28R; DNA; Artificial> ATCCGTCACACCTGCTCTCATTCGTGCCCGTCATTTAGCGATGTCTTTTCTAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 441 29F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACAAATGAATAAAATTTCGGAAAAGGCAAGCAGGATAAGAGCAGGTGTGACGGAT <SEQ ID NO. 442 29R; DNA; Artificial> ATCCGTCACACCTGCTCTTATCCTGCTTGCCTTTTCCGAAATTTTATTCATTTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 443 30F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATTATGTTAACAAAGGCATACGGCAAGCTCTAACTGTAGAGCAGGTGTGA CGGAT <SEQ ID NO. 444 30R; DNA; Artificial> ATCCGTCACACCTGCTCTACAGTTAGAGCTTGCCGTATGCCTTTGTTAACATAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 445 31F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATAAGAACCACCACTCCGCGTTCGCCTCCCGAGGTGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 446 31R; DNA; Artificial> ATCCGTCACACCTGCTCTACACCTCGGGAGGCGAACGCGGAGTGGTGGTTCTTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 447 33F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCATGGCGATACAGTTATCTGCATTGTTCCATCCCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 448 33R; DNA; Artificial> ATCCGTCACACCTGCTCTAGGGATGGAACAATGCAGATAACTGTATCGCCATGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 449 34F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCCCTGGGCCAGCCCGTGACTTTCCCCCGGCGTCCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 450 34R; DNA; Artificial> ATCCGTCACACCTGCTCTTGGACGCCGGGGGAAAGTCACGGGCTGGCCCAGGGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 451 35F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAAACGGTTCAGAAATAGGAAACGTTTGATCGCAAGAAGAGCAGGTGTGACGGAT <SEQ ID NO. 452 35R; DNA; Artificial> ATCCGTCACACCTGCTCTTCTTGCGATCAAACGTTTCCTATTTCTGAACCGTTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 453 36F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGAATATCTAAAATAAAGGAAAGACAACCGCGGATGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 454 36R; DNA; Artificial> ATCCGTCACACCTGCTCTGCATCCGCGGTTGTCTTTCCTTTATTTTAGATATTCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 455 37F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGACGGGCGTAAAGAAATAACCAATGCTACCGCCACAGAGCAGGTGTGACGGAT <SEQ ID NO. 456 37R; DNA; Artificial> ATCCGTCACACCTGCTCTGTGGCGGTAGCATTGGTTATTTCTTTACGCCCGTCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 457 38F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAACGAATAAGTATTTAAGACAGAATTAGACACTTAGAAGAGCAGGTGTGACGGAT <SEQ ID NO. 458 38R; DNA; Artificial> ATCCGTCACACCTGCTCTTCTAAGTGTCTAATTCTGTCTTAAATACTTATTCGTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 459 39F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATATACATACTCCTCGCTACAACCGCTGCGCCGGATCAGAGCAGGTGTGACGGAT <SEQ ID NO. 460 39R; DNA; Artificial> ATCCGTCACACCTGCTCTGATCCGGCGCAGCGGTTGTAGCGAGGAGTATGTATATGGTGTTGGCTCCCGTAT <SEQ ID NO. 461 40F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATATAAGCGAGGAGGAAGGCGGCGAGCTATAAGTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 462 40R; DNA; Artificial> ATCCGTCACACCTGCTCTGACTTATAGCTCGCCGCCTTCCTCCTCGCTTATATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 463 LP 21F; DNA; ARTIFICIAL> CATACGGGAGCCAACACCACAACCATTGCGTTACTATCTTCAGAGCAGGTGTGACGGATG <SEQ ID NO. 464 LP 21R; DNA; Artificial> CATCCGTCACACCTGCTCTGAAGATAGTAACGCAATGGTTGTGGTGTTGGCTCCCGTATG <SEQ ID NO. 465 L. major LRC 940 3F; DNA; ARTIFICIAL> CATACGGGAGCCAACACCACCCGTATCGTTCCCAATGCACTCAGAGCAGGTGTGACGGATG <SEQ ID NO. 466 L. major LRC 940 3R; DNA; Artificial> CATCCGTCACACCTGCTCTGAGTGCATTGGGAACGATACGGGTGGTGTTGGCTCCCGTATG <SEQ ID NO. 467 L. major LRC 940-5F; DNA; ARTIFICIAL> CATACGGGAGCCAACACCACGTTCCCATACAAGTTACTGACAGAGCAGGTGTGACGGATA <SEQ ID NO. 468 L. major LRC 940-5R; DNA; Artificial> TATCCGTCACACCTGCTCTGTCAGTAACTTGTATGGGAACGTGGTGTTGGCTCCCGTATG <SEQ ID NO. 469 L. major LRC 940-6F; DNA; ARTIFICIAL> CATACGGGAGCCAACACCACAATGTCTTGCTCGTGTGTCCCAGAGCAGGTGTGACGGATG <SEQ ID NO. 470 L. major LRC 940-6R; DNA; Artificial> CATCCGTCACACCTGCTCTGGGACACACGAGCAAGACATTGTGGTGTTGGCTCCCGTATG <SEQ ID NO. 471 L. major LRC 940 18.2F; DNA; ARTIFICIAL> CATACGGGAGCCAACACCACTCTCAGAATGGGTCCAACCCCAGAGCAGGTGTGACGGATG <SEQ ID NO. 472 L. major LRC 940 18.2R; DNA; Artificial> CATCCGTCACACCTGCTCTGGGGTTGGACCCATTCTGAGAGTGGTGTTGGCTCCCGTATG <SEQ ID NO. 473 25F; DNA; ARTIFICIAL> CATACGGGAGCCAACACCACGTGTTGATGCGGGGTTCTCGCAGAGCAGGTGTGACGGATG <SEQ ID NO. 474 25R; DNA; Artificial> CATCCGTCACACCTGCTCTGCGAGAACCCCGCATCAACACGTGGTGTTGGCTCCCGTATG <SEQ ID NO. 475 29F; DNA; ARTIFICIAL> CATACGGGAGCCAACACCACCCGCAGCATCCATAAACGAGCAGAGCAGGTGTGACGGATG <SEQ ID NO. 476 29R; DNA; Artificial> CATCCGTCACACCTGCTCTGCTCGTTTATGGATGCTGCGGGTGGTGTTGGCTCCCGTATG <SEQ ID NO. 477 Lm 1F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTATCGTGTCTTATTTATTCTGCTCAATACGTTACGCTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 478 Lm 1R; DNA; Artificial> ATACGGGAGCCAACACCAAGCGTAACGTATTGAGCAGAATAAATAAGACACGATAGAGCAGGTGTGACGGAT <SEQ ID NO. 479 Lm 2/41F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAACCTGGCTATCTGCATGCGGTCGGTCGCCTTGTTGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 480 Lm 2/41R; DNA; Artificial> ATCCGTCACACCTGCTCTCCAACAAGGCGACCGACCGCATGCAGATAGCCAGGTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 481 Lm 3F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTTCACGTGTAGCGATGACAGAATAAGGATTGAAAGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 482 Lm 3R; DNA; Artificial> ATACGGGAGCCAACACCAGTCTTTCAATCCTTATTCTGTCATCGCTACACGTGAAGAGCAGGTGTGACGGAT <SEQ ID NO. 483 Lm 4F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTGAGGTCGGGTATTAGTCCGTATAAACCGAGACTGAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 484 Lm 4R; DNA; Artificial> ATACGGGAGCCAACACCATTCAGTCTCGGTTTATACGGACTAATACCCGACCTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 485 Lm 5F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCGATACACGTCCATCGAACAAGTTAAAACTTAGAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 486 Lm 5R; DNA; Artificial> ATCCGTCACACCTGCTCTTTCTAAGTTTTAACTTGTTCGATGGACGTGTATCGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 487 Lm 6/10F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGGGGGCATCTTCCATTAACCCATTACCTCACCCCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 488 Lm 6/10R; DNA; Artificial> ATCCGTCACACCTGCTCTTGGGGTGAGGTAATGGGTTAATGGAAGATGCCCCCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 489 Lm 7F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACGCCCACGGCCACGCCCGACGAGCTACCCCTCATCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 490 Lm 7R; DNA; Artificial> ATCCGTCACACCTGCTCTTGATGAGGGGTAGCTCGTCGGGCGTGGCCGTGGGCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 491 Lm 9F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTCGCATCTAACGTCTAGACTATCAAAAGTCGTGTTAATGGTGTTGGTTCCGGTAT <SEQ ID NO. 492 Lm 9R; DNA; Artificial> ATACCGGAACCAACACCATTAACACGACTTTTGATAGTCTAGACGTTAGATGCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 493 Lm 11/47F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTTGGGGTGAGGTAATGGGTTAATGGAAGATGCCCCCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 494 Lm 11/47R; DNA; Artificial> ATACGGGAGCCAACACCACGGGGGCATCTTCCATTAACCCATTACCTCACCCCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 495 Lm 13F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACAAAGTTTAGCGTTATGCAACTCCCCCTTATACTCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 496 Lm 13R; DNA; Artificial> ATCCGTCACACCTGCTCTCGAGTATAAGGGGGAGTTGCATAACGCTAAACTTTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 497 Lm 14F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGTAATTGTCACTCACGCAGATCGGTGACTACATAGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 498 Lm 14R; DNA; Artificial> ATCCGTCACACCTGCTCTGCTATGTAGTCACCGATCTGCGTGAGTGACAATTACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 499 Lm 15F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTGTGTACTACTTGCAGGAATGGCAATAGGCGGAAAGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 500 Lm 15R; DNA; Artificial> ATACGGGAGCCAACACCACCTTTCCGCCTATTGCCATTCCTGCAAGTAGTACACAGAGCAGGTGTGACGGAT <SEQ ID NO. 501 Lm 16F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTATGTTGCCGGGAAGATATAGTGAAAATTCATGATATGGTGTTGGCTCCCGTAT <SEQ ID NO. 502 Lm 16R; DNA; Artificial> ATACGGGAGCCAACACCATATCATGAATTTTCACTATATCTTCCCGGCAACATAGAGCAGGTGTGACGGAT <SEQ ID NO. 503 Lm 17F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACTGGTGAGGCGCCTGCGCCGACTGGCCGTCCCCCCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 504 Lm 17R; DNA; Artificial> ATCCGTCACACCTGCTCTCGGGGGGACGGCCAGTCGGCGCAGGCGCCTCACCAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 505 Lm 18F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTGGGTGAGCGAGTCGGCCCCGGGAGCGAACGGCGGCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 506 Lm 18R; DNA; Artificial> ATACGGGAGCCAACACCACGCCGCCGTTCGCTCCCGGGGCCGACTCGCTCACCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 507 Lm 19F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTCAGCGGCGGCGGGCCCGGGCGATGGAGGTCCTGACATGGTGTTGGCTCCCGTAT <SEQ ID NO. 508 Lm 19R; DNA; Artificial> ATACGGGAGCCAACACCATGTCAGGACCTCCATCGCCCGGGCCCGCCGCCGCTGAGAGCAGGTGTGACGGAT <SEQ ID NO. 509 Lm 21F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTTTCCATGTATATTAGATACTCGGGGCAAGGGGAAACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 510 Lm 21R; DNA; Artificial> ATACGGGAGCCAACACCAGTTTCCCCTTGCCCCGAGTATCTAATATACATGGAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 511 Lm 22F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTGGAGCGATCTAACCCTTTTTATCAATCAATTCGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 512 Lm 22R; DNA; Artificial> ATACGGGAGCCAACACCACCGAATTGATTGATAAAAAGGGTTAGATCGCTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 513 Lm 23F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTTGGGACATTTGTAGTGCCTGTTCATGTATCGCAGCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 514 Lm 23R; DNA; Artificial> ATACGGGAGCCAACACCAGGCTGCGATACATGAACAGGCACTACAAATGTCCCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 515 Lm 25F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACCCACTCTCCCCCCGCTCCCGCTCCCCCGCTCCGCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 516 Lm 25R; DNA; Artificial> ATCCGTCACACCTGCTCTCGCGGAGCGGGGGAGCGGGAGCGGGGGGAGAGTGGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 517 Lm 26/43F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTACATCACATCTGACTGAGTCCATGGCGCTCTGTGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 518 Lm 26/43R; DNA; Artificial> ATACGGGAGCCAACACCACACACAGAGCGCCATGGACTCAGTCAGATGTGATGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 519 Lm 27F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCCTCCTGCGGCGTCTGGAGAACAGCCTCTACTTTAAGAGCAGGTGTGACGGAT <SEQ ID NO. 520 Lm 27R; DNA; Artificial> ATCCGTCACACCTGCTCTTAAAGTAGAGGCTGTTCTCCAGACGCCGCAGGAGGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 521 Lm 29F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTTTTTGGTATTGTTGGCGGAAGGCGGTGGTTCGTGTCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 522 Lm 29R; DNA; Artificial> ATACGGGAGCCAACACCAGACACGAACCACCGCCTTCCGCCAACAATACCAAAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 523 Lm 31F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATAGTACCGCGCCCGGCGAAAAAGCTCCTTTAATACAGAGCAGGTGTGACGGAT <SEQ ID NO. 524 Lm 31R; DNA; Artificial> ATCCGTCACACCTGCTCTGTATTAAAGGAGCTTTTTCGCCGGGCGCGGTACTATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 525 Lm 32/40F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAATAGATGGATAAGGGGGAAACTGCCATTCGGTTAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 526 Lm 32/40R; DNA; Artificial> ATCCGTCACACCTGCTCTACTAACCGAATGGCAGTTTCCCCCTTATCCATCTATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 527 Lm 34F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTTGGGTCGGCCGGGACCAGCGCGGCGGCCTCCTGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 528 Lm 34R; DNA; Artificial> ATACGGGAGCCAACACCACCAGGAGGCCGCCGCGCTGGTCCCGGCCGACCCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 529 Lm 35F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTATGTTACAACCGCCACAAGTAGGTTTGATACCCGGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 530 Lm 35R; DNA; Artificial> ATACGGGAGCCAACACCACCCGGGTATCAAACCTACTTGTGGCGGTTGTAACATAGAGCAGGTGTGACGGAT <SEQ ID NO. 531 Lm 36F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACACACAGAGCGCATGGACTCAGTCAGATGTGATGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 532 Lm 36R; DNA; Artificial> ATCCGTCACACCTGCTCTACATCACATCTGACTGAGTCCATGCGCTCTGTGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 533 Lm 37F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCACTACTTTTATAATTTCATTCTTCTGGCGTCCCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 534 Lm 37R; DNA; Artificial> ATCCGTCACACCTGCTCTAGGGACGCCAGAAGAATGAAATTATAAAAGTAGTGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 535 Lm 38F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTTGTTACAACCTAGTACCCGGAGGGGGACCCGAGGAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 536 Lm 38R; DNA; Artificial> ATACGGGAGCCAACACCACTCCTCGGGTCCCCCTCCGGGTACTAGGTTGTAACAAGAGCAGGTGTGACGGAT <SEQ ID NO. 537 Lm 39F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTGTTTCTTCAACTTCTGCCTTATCCCCGGTCGGTACGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 538 Lm 39R; DNA; Artificial> ATACGGGAGCCAACACCACGTACCGACCGGGGATAAGGCAGAAGTTGAAGAAACAGAGCAGGTGTGACGGAT <SEQ ID NO. 539 Lm 42F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCATCACGGCAATGTCCGATAATGTCTTGCTTCAGCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 540 Lm 42R; DNA; Artificial> ATCCGTCACACCTGCTCTCGCTGAAGCAAGACATTATCGGACATTGCCGTGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 541 Lm 44F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTGAGGAATATGACGCGGCAATAGTGAACCAGTCAAACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 542 Lm 44R; DNA; Artificial> ATACGGGAGCCAACACCAGTTTGACTGGTTCACTATTGCCGCGTCATATTCCTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 543 Lm 45F; DNA; ARTIFICIAL> ATCCGTCACACCTGCTCTGCATGGCCATCCAGATTAGTCTTGCAGCACATTCGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 544 Lm 45R; DNA; Artificial> ATACGGGAGCCAACACCACCGAATGTGCTGCAAGACTAATCTGGATGGCCATGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 545 Lm 46F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCACACCTGGTAAATTTACCACGGCTTACTTGCTCAGATAGAGCAGGTGTGACGGAT <SEQ ID NO. 546 Lm 46R; DNA; Artificial> ATCCGTCACACCTGCTCTATCTGAGCAAGTAAGCCGTGGTAAATTTACCAGGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 547 Lm 49/49F; DNA; ARTIFICIAL> ATACGGGAGCCAACACCAGCACACGGCACGCCCCTCCGAACCACGCCCCCGAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 548 Lm 49/49R; DNA; Artificial> ATCCGTCACACCTGCTCTTTCGGGGGCGTGGTTCGGAGGGGCGTGCCGTGTGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 549 Rp-1/4/6/12F; DNA; Artificial> ATACGGGAGCCAACACCATCCAATGAGGCCATGGACCGGTAAACTCGGACGCGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 550 Rp-1/4/6/12R; DNA; Artificial> ATCCGTCACACCTGCTCTGCGCGTCCGAGTTTACCGGTCCATGGCCTCATTGGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 551 Rp-3F; DNA; Artificial> ATACGGGAGCCAACACCACACGCCACAAACCCCACTCCGTGCCGTGCCCGCCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 552 Rp-3R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGGCGGGCACGGCACGGAGTGGGGTTTGTGGCGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 553 Rp-5F; DNA; Artificial> ATACGGGAGCCAACACCACCTGGAGCCCAGCCTGTACTCATCTCACCGCCGTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 554 Rp-5R; DNA; Artificial> ATCCGTCACACCTGCTCTGGACGGCGGTGAGATGAGTACAGGCTGGGCTCCAGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 555 Rp-7F; DNA; Artificial> ATACGGGAGCCAACACCAGGCGCCGTACAGCGGTCCGCTACCGACCTATTGTGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 556 Rp-7R; DNA; Artificial> ATCCGTCACACCTGCTCTACACAATAGGTCGGTAGCGGACCGCTGTACGGCGCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 557 Rp-8F; DNA; Artificial> ATACGGGAGCCAACACCATACGTCCCACAAAGCGATCGGCTGGATACTTCGTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 558 Rp-8R; DNA; Artificial> ATCCGTCACACCTGCTCTGACGAAGTATCCAGCCGATCGCTTTGTGGGACGTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 559 Rp-9F; DNA; Artificial> ATACGGGAGCCAACACCACAGAATGTCGATGCACAGGGGAATTCGGTGCGCCCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 560 Rp-9R; DNA; Artificial> ATCCGTCACACCTGCTCTCGGGCGCACCGAATTCCCCTGTGCATCGACATTCTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 561 Rp-10F; DNA; Artificial> ATACGGGAGCCAACACCACTCTAGCTGACAGGTGCATACGATACCCGACGCTTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 562 Rp-10R; DNA; Artificial> ATCCGTCACACCTGCTCTGAAGCGTCGGGTATCGTATGCACCTGTCAGCTAGAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 563 Rp-11F; DNA; Artificial> ATACGGGAGCCAACACCAGGTCCGTCAAACGTTACGTAGGAGGCATATCACGGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 564 Rp-11R; DNA; Artificial> ATCCGTCACACCTGCTCTACCGTGATATGCCTCCTACGTAACGTTTGACGGACCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 565 Rp-13F; DNA; Artificial> ATACGGGAGCCAACACCATGCATACGAGGCCACCACTCAGAAAGATATGTGGGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 566 Rp-13R; DNA; Artificial> ATCCGTCACACCTGCTCTGCCCACATATCTTTCTGAGTGGTGGCCTCGTATGCATGGTGTTGGCTCCCGTAT <SEQ ID NO. 567 Rp-14F; DNA; Artificial> ATACGGGAGCCAACACCAGCCCACTGCCACGATATATGCGCAACCGTTGTCCGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 568 Rp-14R; DNA; Artificial> ATCCGTCACACCTGCTCTGCGGACAACGGTTGCGCATATATCGTGGCAGTGGGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 569 Rp-15F; DNA; Artificial> ATACGGGAGCCAACACCAACCGACACCCCCGCCCAGCCCCATCCTGCCCGGTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 570 Rp-15R; DNA; Artificial> ATCCGTCACACCTGCTCTGGACCGGGCAGGATGGGGCTGGGCGGGGGTGTCGGTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 571 Rp-16F; DNA; Artificial> ATACGGGAGCCAACACCATGCGGGGAGCAATGTAGGTCTTAGTACCACGTGGCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 572 Rp-16R; DNA; Artificial> ATCCGTCACACCTGCTCTGGCCACGTGGTACTAAGACCTACATTGCTCCCCGCATGGTGTTGGCTCCCGTAT <SEQ ID NO. 573 Rp-17F; DNA; Artificial> ATACGGGAGCCAACACCAGCCGTACTAGGCCCGAAGTCAGGTGTAGGATTGGCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 574 Rp-17R; DNA; Artificial> ATCCGTCACACCTGCTCTGGCCAATCCTACACCTGACTTCGGGCCTAGTACGGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 575 Rp-19F; DNA; Artificial> ATACGGGAGCCAACACCACATCCCACACACGAACAGTACCTTGCCACCCCCGCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 576 Rp-19R; DNA; Artificial> ATCCGTCACACCTGCTCTGGCGGGGGTGGCAAGGTACTGTTCGTGTGTGGGATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 577 Rp-20F; DNA; Artificial> ATACGGGAGCCAACACCACCTGTCCACTTTGGCACGCGCGCCACTCAGTCCTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 578 Rp-20R; DNA; Artificial> ATCCGTCACACCTGCTCTGGAGGACTGAGTGGCGCGCGTGCCAAAGTGGACAGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 579 Rr-3F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 580 Rr-3R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 581 Rr-7F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 582 Rr-7R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 583 Rr-8/14/22F; DNA; Artificial> ATACGGGAGCCAACACCACAAGCAGGAATAAGCGCCGGTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 584 Rr-8/14/22R; DNA; Artificial> ATCCGTCACACCTGCTCTGGACCGGCGCTTATTCCTGCTTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 585 Rr-9F; DNA; Artificial> ATACGGGAGCCAACACCAGCGAACTGAAAACGCTTAAAGGAGACCAATGACCGAAGAGCAGGTGTGACGGA <SEQ ID NO. 586 Rr-9R; DNA; Artificial> ATCCGTCACACCTGCTCTTCGGTCATTGGTCTCCTTTAAGCGTTTTCAGTTCGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 587 Rr-10F; DNA; Artificial> ATACGGGAGCCAACACCAAGTCATGCCGAAGTAGGGTAACGTCTGAATGGTAGAAGAGCAGGTGTGACGGAT <SEQ ID NO. 588 Rr-10R; DNA; Artificial> ATCCGTCACACCTGCTCTTCTACCATTCAGACGTTACCCTACTTCGGCATGACTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 589 Rr-11F; DNA; Artificial> ATACGGGAGCCAACACCACTCGTAATCCTTTAATACACCTATTGCAACAATGCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 590 Rr-11R; DNA; Artificial> ATCCGTCACACCTGCTCTAGCATTGTTGCAATAGGTGTATTAAAGGATTACGAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 591 Rr-12F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 592 Rr-12R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 593 Rr-13F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 594 Rr-13R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 595 Rr-15F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 596 Rr-15R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 597 Rr-16F; DNA; Artificial> ATACGGGAGCCAACACCACACTACCGTCCCACCCCCTCCCAGCTCCTCCGGCCGAGAGCAGGTGTGACGGA <SEQ ID NO. 598 Rr-16R; DNA; Artificial> ATCCGTCACACCTGCTCTCGGCCGGAGGAGCTGGGAGGGGGTGGGACGGTAGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 599 Rr-17F; DNA; Artificial> ATACGGGAGCCAACACCAAGGGGCAACTCGAACCCGGGCGATACCGAGACTGACAGAGCAGGTGTGACGGAT <SEQ ID NO. 600 Rr-17R; DNA; Artificial> ATCCGTCACACCTGCTCTGTCAGTCTCGGTATCGCCCGGGTTCGAGTTGCCCCTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 601 Rr-18F; DNA; Artificial> ATACGGGAGCCAACACCACGATCCTACTCATACGGAGCCCTGGCTGACTCGCGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 602 Rr-18R; DNA; Artificial> ATCCGTCACACCTGCTCTGCGCGAGTCAGCCAGGGCTCCGTATGAGTAGGATCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 603 Rr-19F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 604 Rr-19R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 605 Rr-20F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 606 Rr-20R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 607 Rr-21F; DNA; Artificial> ATACGGGAGCCAACACCACTGAAAACTTATGAAATGCCGGTCGCAGATTTTGTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 608 Rr-21R; DNA; Artificial> ATCCGTCACACCTGCTCTGACAAAATCTGCGACCGGCATTTCATAAGTTTTCAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 609 Rr-23F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 610 Rr-23R; DNA; Artificial> ATCCGTCACACCTGCTCTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 611 Rr-24F; DNA; Artificial> ATACGGGAGCCAACACCACACTACCGTCCCACCCCCTCCCAGCTCCTCCGGCCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 612 Rr-24R; DNA; Artificial> ATCCGTCACACCTGCTCTCGGCCGGAGGAGCTGGGAGGGGGTGGGACGGTAGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 613 Rr-25F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 614 Rr-25R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 615 Rt-1F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 616 Rt-1R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 617 Rt-2F; DNA; Artificial> ATACGGGAGCCAACACCACCGCAACACACTATCCACGACCAGAGCAGGTGTGACGGAT <SEQ ID NO. 618 Rt-2R; DNA; Artificial> ATCCGTCACACCTGCTCTGGTCGTGGATAGTGTGTTGCGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 619 Rt-3F; DNA; Artificial> ATACGGGAGCCAACACCACCGCCCGCCTCCTGGCGCCACACCCCCGCCGCAGCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 620 Rt-3R; DNA; Artificial> ATCCGTCACACCTGCTCTCGCTGCGGCGGGGGTGTGGCGCCAGGAGGCGGGCGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 621 Rt-4F; DNA; Artificial> ATACGGGAGCCAACACCAAATACAGTGCCTAATAGGTATGAAAATTATAGTAATAGAGCAGGTGTGACGGAT <SEQ ID NO. 622 Rt-4R; DNA; Artificial> ATCCGTCACACCTGCTCTATTACTATAATTTTCATACCTATTAGGCACTGTATTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 623 Rt-5/16F; DNA; Artificial> ATACGGGAGCCAACACCACACTACCGTCCCACCCCCTCCCAGCTCCTCCGGCCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 624 Rt-5/16R; DNA; Artificial> ATCCGTCACACCTGCTCTCGGCCGGAGGAGCTGGGAGGGGGTGGGACGGTAGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 625 Rt-6F; DNA; Artificial> ATACGGGAGCCAACACCACTAGTTATTTCATAGGGGAAATTAACAAATTTTGACAGAGCAGGTGTGACGGAT <SEQ ID NO. 626 Rt-6R; DNA; Artificial> ATCCGTCACACCTGCTCTGTCAAAATTTGTTAATTTCCCCTATGAAATAACTAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 627 Rt-7aF; DNA; Artificial> ATACGGGAGCCAACACCACGGACAATCTGGTAGTAGTAAACAATATATAAGTATAGAGCAGGTGTGACGGAT <SEQ ID NO. 628 Rt-7aR; DNA; Artificial> ATCCGTCACACCTGCTCTATACTTATATATTGTTTACTACTACCAGATTGTCCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 629 Rt-7bF; DNA; Artificial> ATACGGGAGCCAACACCAGTACTCGCTGTGGCAAAAGCAGCATTTCGTCTATCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 630 Rt-7bR; DNA; Artificial> ATCCGTCACACCTGCTCTAGATAGACGAAATGCTGCTTTTGCCACAGCGAGTACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 631 Rt-8F; DNA; Artificial> ATACGGGAGCCAACACCAAAGCTCCCCCCCTCATCCCTGGCATCTCCGCTAACCAGAGCAGGTGTGACGGAT <SEQ ID NO. 632 Rt-8R; DNA; Artificial> ATCCGTCACACCTGCTCTGGTTAGCGGAGATGCCAGGGATGAGGGGGGGAGCTTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 633 Rt-9F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 634 Rt-9R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 635 Rt-10F; DNA; Artificial> ATACGGGAGCCAACACCATTAACGTCGCAATAGCGCTCATCTAACGTCAAGGGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 636 Rt-10R; DNA; Artificial> ATCCGTCACACCTGCTCTGCCCTTGACGTTAGATGAGCGCTATTGCGACGTTAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 637 Rt-11F; DNA; Artificial> ATACGGGAGCCAACACCAAAGTGTCGTAATTTAAGATGCATACGCATGCCGTTAAGAGCAGGTGTGACGGAT <SEQ ID NO. 638 Rt-11R; DNA; Artificial> ATCCGTCACACCTGCTCTTAACGGCATGCGTATGCATCTTAAATTACGACACTTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 639 Rt-12F; DNA; Artificial> ATACGGGAGCCAACACCAGTGTCTTATGAATGTAGATGAGCTCAGATCGGAATTAGAGCAGGTGTGACGGAT <SEQ ID NO. 640 Rt-12R; DNA; Artificial> ATCCGTCACACCTGCTCTAATTCCGATCTGAGCTCATCTACATTCATAAGACACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 641 Rt-13F; DNA; Artificial> ATACGGGAGCCAACACCACACATCACATACCTTCAAGAGCGATGACGGCCCTTTATAGGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 642 Rt-13R; DNA; Artificial> ATCCGTCACACCTGCTCTGCCTATAAAGGGCCGTCATCGCTCTTGAAGGTATGTGATGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 643 Rt-16F; DNA; Artificial> ATACGGGAGCCAACACCACACTACCGTCCCACCCCCTCCCAGCTCCTCCGGCCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 644 Rt-16R; DNA; Artificial> ATCCGTCACACCTGCTCTCGGCCGGAGGAGCTGGGAGGGGGTGGGACGGTAGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 645 Rt-17F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 646 Rt-17R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 647 Rt-18F; DNA; Artificial> ATACGGGAGCCAACACCAATGTGGTGGATAGCAAACCCCCGACGATTGAGGATTAGAGCAGGTGTGACGGAT <SEQ ID NO. 648 Rt-18R; DNA; Artificial> ATCCGTCACACCTGCTCTAATCCTCAATCGTCGGGGGTTTGCTATCCACCACATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 649 Rt-19F; DNA; Artificial> ATACGGGAGCCAACACCAGTTGAAGCTAGTACTGCGGAAGCATAGTCCATAAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 650 Rt-19R; DNA; Artificial> ATCCGTCACACCTGCTCTACTTATGGACTATGCTTCCGCAGTACTAGCTTCAACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 651 Rt-20F; DNA; Artificial> ATACGGGAGCCAACACCAGCGAAATGAAGGTATGTTTTTGAATAATAATGTGGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 652 Rt-20R; DNA; Artificial> ATCCGTCACACCTGCTCTGCCACATTATTATTCAAAAACATACCTTCATTTCGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 653 Rt-12F; DNA; Artificial> ATACGGGAGCCAACACCAAAATAGATCAAAACCGCATGCTGGAGCAGTTTTAGCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 654 Rt-21R; DNA; Artificial> ATCCGTCACACCTGCTCTTGCTAAAACTGCTCCAGCATGCGGTTTTGATCTATTTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 655 Rt-22F; DNA; Artificial> ATACGGGAGCCAACACCAATAATTGCTCGTTGATACTTATATAAAGTACAGGCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 656 Rt-22R; DNA; Artificial> ATCCGTCACACCTGCTCTTGCCTGTACTTTATATAAGTATCAACGAGCAATTATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 657 Rt-23F; DNA; Artificial> ATACGGGAGCCAACACCATCCAATGAGGCCATGGACCGGTAAACTCGGACGCGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 658 Rt-23R; DNA; Artificial> ATCCGTCACACCTGCTCTGCGCGTCCGAGTTTACCGGTCCATGGCCTCATTGGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 659 Rt-24F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 660 Rt-24R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 661 Rt-25F; DNA; Artificial> ATACGGGAGCCAACACCAAGACGATAAGAATAATATCGAAAATATATGTTTTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 662 Rt-25R; DNA; Artificial> ATCCGTCACACCTGCTCTGAAAACATATATTTTCGATATTATTCTTATCGTCTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 663 E7A-1F; DNA; Artificial> ATACGGGAGCCAACACCAGCCTCGCCTTCAGATGTTCACTGCTGTTTATTGCATAGAGCAGGTGTGACGGAT <SEQ ID NO. 664 E7A-1R; DNA; Artificial> ATCCGTCACACCTGCTCTATGCAATAAACAGCAGTGAACATCTGAAGGCGAGGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 665 E7A-2/6/28/30bF; DNA; Artificial> ATACGGGAGCCAACACCAATAGATGGATAAGGGGGAAACTGCCATTCGGTTAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 666 E7A-2/6/28/30bR; DNA; Artificial> ATCCGTCACACCTGCTCTACTAACCGAATGGCAGTTTCCCCCTTATCCATCTATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 667 E7A-3/10/16/19/21/22F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 668 E7A-3/10/16/19/21/22R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 669 E7A-4F; DNA; Artificial> ATACGGGAGCCAACACCAGGACTCGCGCAAATAATTTTTATACGCACCACTTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 670 E7A-4R; DNA; Artificial> ATCCGTCACACCTGCTCTGAAGTGGTGCGTATAAAAATTATTTGCGCGAGTCCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 671 E7A-5F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 672 E7A-5R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 673 E7A-7F; DNA; Artificial> ATACGGGAGCCAACACCATAAAGCTCGTATTGCCACCCCCCTGTTATTTAATACAGAGCAGGTGTGACGGAT <SEQ ID NO. 674 E7A-7R; DNA; Artificial> ATCCGTCACACCTGCTCTGTATTAAATAACAGGGGGGTGGCAATACGAGCTTTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 675 E7A-8F; DNA; Artificial> ATACGGGAGCCAACACCATCACGGCAATGTCCCGATAATGTCTTGCTTCAGCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 676 E7A-8R; DNA; Artificial> ATCCGTCACACCTGCTCTCGCTGAAGCAAGACATTATCGGGACATTGCCGTGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 677 E7A-11F; DNA; Artificial> ATACGGGAGCCAACACCAGCAGTACTAACCCCCCTTACCATATATATCACACGAGAGCAGGTGTGACGGAT <SEQ ID NO. 678 E7A-11R; DNA; Artificial> ATCCGTCACACCTGCTCTCGTGTGATATATATGGTAAGGGGGGTTAGTACTGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 679 E7A-12/30a/32/34F; DNA; Artificial> ATACGGGAGCCAACACCACCCTAAATTCCAGAGTGTACAAGAGAACGAACTACCAGAGCAGGTGTGACGGAT <SEQ ID NO. 680 E7A-12/30a/32/34F; DNA; Artificial> ATCCGTCACACCTGCTCTGGTAGTTCGTTCTCTTGTACACTCTGGAATTTAGGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 681 E7A-13F; DNA; Artificial> ATACGGGAGCCAACACCATAGCGACTTGGCAAAAAATTTACATCCATTACTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 682 E7A-13R; DNA; Artificial> ATCCGTCACACCTGCTCTGGAGTAATGGATGTAAATTTTTTGCCAAGTCGCTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 683 E7A-14F; DNA; Artificial> ATACGGGAGCCAACACCACGTACACAAACCAAATACGCACCTTCCCACCCTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 684 E7A-14R; DNA; Artificial> ATCCGTCACACCTGCTCTGGAGGGTGGGAAGGTGCGTATTTGGTTTGTGTACGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 685 E7A-15F; DNA; Artificial> ATACGGGAGCCAACACCACATCTAGCACGAGACCCTATCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 686 E7A-15R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGATAGGGTCTCGTGCTAGATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 687 E7A-17F; DNA; Artificial> ATACGGGAGCCAACACCAAATCGTCAACAGCCCTGCGCCACTTATCTTTTTGCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 688 E7A-17R; DNA; Artificial> ATCCGTCACACCTGCTCTGGCAAAAAGATAAGTGGCGCAGGGCTGTTGACGATTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 689 E7A-18F; DNA; Artificial> ATACGGGAGCCAACACCAACAGATGGATAAGGGGGAAACTGCCCATTCGGTTAGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 690 E7A-18R; DNA; Artificial> ATCCGTCACACCTGCTCTACTAACCGAATGGGCAGTTTCCCCCTTATCCATCTGTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 691 E7A-20F; DNA; Artificial> ATACGGGAGCCAACACCACGCAGTTATAACGGCAGGCCCCATATCGTTTAACCAGAGCAGGTGTGACGGAT <SEQ ID NO. 692 E7A-20R; DNA; Artificial> ATCCGTCACACCTGCTCTGGTTAAACGATATGGGGCCTGCCGTTATAACTGCGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 693 E7A-23F; DNA; Artificial> ATACGGGAGCCAACACCATGTCAGGACCTCCATCGCCCGGGCCCGCCGCCGCTGAGAGCAGGTGTGAC <SEQ ID NO. 694 E7A-23R; DNA; Artificial> GTCACACCTGCTCTCAGCGGCGGCGGGCCCGGGCGATGGAGGTCCTGACATGGTGTTGGCTCCCGTAT <SEQ ID NO. 695 E7A-25F; DNA; Artificial> ATACGGGAGCCAACACCATAACAAATAACCACCCTCAATGCTAGATAGTGGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 696 E7A-25R; DNA; Artificial> ATCCGTCACACCTGCTCTGCCACTATCTAGCATTGAGGGTGGTTATTTGTTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 697 E7A-29F; DNA; Artificial> ATACGGCAGCCAACACCACACACATAGCGCTTTGTATTCAGCCGGATGTGATGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 698 E7A-29F; DNA; Artificial> ATCCGTCACACCTGCTCTACATCACATCCGGCTGAATACAAAGCGCTATGTGTGTGGTGTTGGCTGCCGTAA <SEQ ID NO. 699 E7A-33F; DNA; Artificial> ATACGGGAGCCAACACCACACACAGAGCGCCATGGACTCAGTCAGATGTGATGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 700 E7A-33R; DNA; Artificial> ATCCGTCACACCTGCTCTACATCACATCTGACTGAGTCCATGGCGCTCTGTGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 701 E7A-35F; DNA; Artificial> ATACGGGAGCCAACGCCACAGGCGTGACATCACCCGTACCCTACCTTAGTGCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 702 E7A-35R; DNA; Artificial> ATCCGTCACACCTGCTCTGGCACTAAGGTAGGGTACGGGTGATGTCACGCCTGTGGCGTTGGCTCCCGTAT <SEQ ID NO. 703 E7B-1aF; DNA; Artificial> ATACGGGAGCCAACACCATAATTCAAGAGGATTCCTCAAAATATGAAGCTTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 704 E7B-1aR; DNA; Artificial> ATCCGTCACACCTGCTCTGGAAGCTTCATATTTTGAGGAATCCTCTTGAATTATGGTGTTGGCTCCCGTAT <SEQ ID NO. 705 E7B-1bF; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 706 E7B-1bR; DNA; Artificial> ATCCGTCACACCTGCTCTTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 707 E7B-3F; DNA; Artificial> ATACGGGAGCCAACACCATATCTTATCATAATGTGATGCTAAGAAGGATCCTTTAGAGCAGGTGTGACGGAT <SEQ ID NO. 708 E7B-3R; DNA; Artificial> ATCCGTCACACCTGCTCTAAAGGATCCTTCTTAGCATCACATTATGATAAGATATGGTGTTGGCTCCCGTAT <SEQ ID NO. 709 E7B-4F; DNA; Artificial> ATACGGGAGCCAACACCAGATTGATGTAAGTAGCCCTCAAATGATTTAAAGTTTAGAGCAGGTGTGACGGAT <SEQ ID NO. 710 E7B-4R; DNA; Artificial> ATCCGTCACACCTGCTCTAAACTTTAAATCATTTGAGGGCTACTTACATCAATCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 711 E7B-5F; DNA; Artificial> ATACGGGAGCCAACACCACACTAATTTATCGCATGCATCGCCCGCTGATGCCCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 712 E7B-5R; DNA; Artificial> ATCCGTCACACCTGCTCTTGGGCATCAGCGGGCGATGCATGCGATAAATTAGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 713 E7B-6F; DNA; Artificial> ATACGGGAGCCAACACCACAGAAGTTATTTTGAGAACGCGACCCAAATAGGTTAAGAGCAGGTGTGACGGAT <SEQ ID NO. 714 E7B-6R; DNA; Artificial> ATCCGTCACACCTGCTCTTAACCTATTTGGGTCGCGTTCTCAAAATAACTTCTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 715 E7B-7F; DNA; Artificial> ATACGGGAGCCAACACCATTAATGTAGAACACCACTCTTATTGACAAGCCTATTAGAGCAGGTGTGACGGAT <SEQ ID NO. 716 E7B-7R; DNA; Artificial> ATCCGTCACACCTGCTCTAATAGGCTTGTCAATAAGAGTGGTGTTCTACATTAATGGTGTTGGCTCCCGTAT <SEQ ID NO. 717 E7B-8a/10/16-19/23-25F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 718 E7B-8a/10/16-19/23-25R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 719 E7B-8bF; DNA; Artificial> ATACGGGAGCCAACACCACAGTTTGTAGTGTAACAATGCTAGATAATAATGAAAAGAGCAGGTGTGACGGAT <SEQ ID NO. 720 E7B-8bR; DNA; Artificial> ATCCGTCACACCTGCTCTTTTCATTATTATCTAGCATTGTTACACTACAAACTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 721 E7B-11F; DNA; Artificial> ATACGGGAGCCAACACCAAGCAAATCACCAGAAATCTTTTAACAATCTATTGACAGAGCAGGTGTGACGGAT <SEQ ID NO. 722 E7B-11R; DNA; Artificial> ATCCGTCACACCTGCTCTGTCAATAGATTGTTAAAAGATTTCTGGTGATTTGCTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 723 E7B-12F; DNA; Artificial> ATACGGGAGCCAACACCACACAGGAACTAGAAGAAAGTATCTTTTTTCGATTTAAGAGCAGGTGTGACGGAT <SEQ ID NO. 724 E7B-12R; DNA; Artificial> ATCCGTCACACCTGCTCTTAAATCGAAAAAAGATACTTTCTTCTAGTTCCTGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 725 E7B-13/15F; DNA; Artificial> ATACGGGAGCCAACACCACATCTAGCACGAGACCCTATCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 726 E7B-13/15R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGATAGGGTCTCGTGCTAGATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 727 E7B-14F; DNA; Artificial> ATACGGGAGCCAGCACCATTCCGTTATGACGTGTCCGGACCCGTTCGCGCGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 728 E7B-14R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACGCGCGAACGGGTCCGGACACGTCATAACGGAATGGTGCTGGCTCCCGTAA <SEQ ID NO. 729 E7B-20/21F; DNA; Artificial> ATACGGGAGCCAACACCATCACGGCAATGTCCCGATAATGTCTTGCTTCAGCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 730 E7B-20/21R; DNA; Artificial> ATCCGTCACACCTGCTCTCGCTGAAGCAAGACATTATCGGGACATTGCCGTGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 731 E7B-22F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 732 E7B-22R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACAATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 733 E7B-26F; DNA; Artificial> ATACGGGAGCCAACACCACATACTCAGACGATTACCCAGCGCATGCTTGTAACAGAGCAGGTGTGACGGAT <SEQ ID NO. 734 E7B-26R; DNA; Artificial> ATCCGTCACACCTGCTCTGTTACAAGCATGCGCTGGGTAATCGTCTGAGTATGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 735 E7B-27F; DNA; Artificial> ATACGGGAGCCAACACCACTCTCTAGCCCACGGCGGGGTTTTCTCGCAAGTCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 736 E7B-27R; DNA; Artificial> ATCCGTCACACCTGCTCTGGACTTGCGAGAAAACCCCGCCGTGGGCTAGAGAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 737 E7B-30F; DNA; Artificial> ATACGGGAGCCAACACCAATTGCGCCCTAAGGCTACCCACATTACCCATGTGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 738 E7B-30R; DNA; Artificial> ATCCGTCACACCTGCTCTACACATGGGTAATGTGGGTAGCCTTAGGGCGCAATTGGTGTTGGCTCCCGTAT <SEQ ID NO. 739 E7B-31F; DNA; Artificial> ATACGGGAGCCAACACCAGCTGCTGCTTCAACGAAATCCCAGGCACCCTGACAAGAGCAGGTGTGACGGAT <SEQ ID NO. 740 E7B-31R; DNA; Artificial> ATCCGTCACACCTGCTCTTGTCAGGGTGCCTGGGATTTCGTTGAAGCAGCAGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 741 E7B-33F; DNA; Artificial> ATACGGGAGCCAACACCAGTACCTGATACCGGGGTACATAAACACCAACATCTAGAGCAGGTGTGACGGAT <SEQ ID NO. 742 E7B-33R; DNA; Artificial> ATCCGTCACACCTGCTCTAGATGTTGGTGTTTATGTACCCCGGTATCAGGTACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 743 E7B-34F; DNA; Artificial> ATACGGGAGCCAACACCAGATACCGTGAATATACTAATTTCGCAATAGTTAATAGAGCAGGTGTGACGGAT <SEQ ID NO. 744 E7B-34R; DNA; Artificial> ATCCGTCACACCTGCTCTATTAACTATTGCGAAATTAGTATATTCACGGTATCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 745 IbAr 10200 - 2-6/8-23/25/26/28/30/31/33/34F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 746 IbAr 10200 - 2-6/8-23/25/26/28/30/31/33/34R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 747 Drosdov - 4-7/10-12/14/18/20-24F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 748 Drosdov - 4-7/10-12/14/18/20-24R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 749 Drosdov - 13F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTTGACATGTCCGGACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT <SEQ ID NO. 750 Drosdov - 13R; DNA; Artificial> ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGGACATGTCAAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 751 Drosdov - 16F; DNA; Artificial> ATACGGGAGCCAACACCATCACGGCAATGTCCCGATAATGTCTTGCTTCAGCGAGAGCAGGTGTGACGGAT <SEQ ID NO. 752 Drosdov - 16RF; DNA; Artificial> ATCCGTCACACCTGCTCTCGCTGAAGCAAGACATTATCGGGACATTGCCGTGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 753 Drosdov - 17F; DNA; Artificial> ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGGACCCGTACAAGAGCAGGTGTGACGGAT <SEQ ID NO. 754 Drosdov - 17R; DNA; Artificial> ATCCGTCACACCTGCTCTTGTACGGGTCCGGACATGTCATAACGGACTGGTGTTGGCTCCCGTAT <SEQ ID NO. 755 Drosdov - 19F; DNA; Artificial> ATACGGGAGCCAACACCAAGTCCAAGCCAAACAAGAGCATAACACCAAATCTGGAGAGCAGGTGTGACGGAT <SEQ ID NO. 756 Drosdov - 19R; DNA; Artificial> ATCCGTCACACCTGCTCTCCAGATTTGGTGTTATGCTCTTGTTTGGCTTGGACTTGGTGTTGGCTCCCGTAT <SEQ ID NO. 757 TBEV-1F; DNA; Artificial> ATACGGGAGCCAACACCACTCGGCACCGCCCTTCCGTATCGGCGAGTAACGTACAGAGCAGGTGTGACGGAT <SEQ ID NO. 758 TBEV-1R; DNA; Artificial> ATCCGTCACACCTGCTCTGTACGTTACTCGCCGATACGGAAGGGCGGTGCCGAGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 759 TBEV-2F; DNA; Artificial> ATACGGGAGCCAACACCACCGCAGGAGTCCATCAGGGGTTGGCAGTCAGCGCTCAGAGCAGGTGTGACGGAT <SEQ ID NO. 760 TBEV-2R; DNA; Artificial> ATCCGTCACACCTGCTCTGAGCGCTGACTGCCAACCCCTGATGGACTCCTGCGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 761 TBEV-3F; DNA; Artificial> ATACGGGAGCCAACACCACACGAACGGAGTGCACCGGGGAAGATACTCCAACGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 762 TBEV-3R; DNA; Artificial> ATCCGTCACACCTGCTCTGCGTTGGAGTATCTTCCCCGGTGCACTCCGTTCGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 763 TBEV-4F; DNA; Artificial> ATACGGGAGCCAACACCAGCCAATTATACAGGTAGGTCAAAAAAGTTTAGGGGAAGAGCAGGTGTGACGGAT <SEQ ID NO. 764 TBEV-4R; DNA; Artificial> ATCCGTCACACCTGCTCTTCCCCTAAACTTTTTTGACCTACCTGTATAATTGGCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 765 TBEV-5F; DNA; Artificial> ATACGGGAGCCAACACCACCATGCCCCTTTAAGTGAATAGACTAGTGGCCGTTGAGAGCAGGTGTGACGGAT <SEQ ID NO. 766 TBEV-5R; DNA; Artificial> ATCCGTCACACCTGCTCTCAACGGCCACTAGTCTATTCACTTAAAGGGGCATGGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 767 TBEV-6F; DNA; Artificial> ATACGGGAGCCAACACCAGAGACGTCTTAGCCTCGCGATCCCGTCCGTTGGCCCAGAGCAGGTGTGACGGAT <SEQ ID NO. 768 TBEV-6R; DNA; Artificial> ATCCGTCACACCTGCTCTGGGCCAACGGACGGGATCGCGAGGCTAAGACGTCTCTGGTGTTGGCTCCCGTAT <SEQ ID NO. 769 TBEV-7F; DNA; Artificial> ATACGGGAGCCAACACCATCCTCCCGCGACGTCTGGAGAACAGCCTCTACTTTAAGAGCAGGTGTGACGGAT <SEQ ID NO. 770 TBEV-7R; DNA; Artificial> ATCCGTCACACCTGCTCTTAAAGTAGAGGCTGTTCTCCAGACGTCGCGGGAGGATGGTGTTGGCTCCCGTAT <SEQ ID NO. 771 TBEV-8F; DNA; Artificial> ATACGGGAGCCAACACCACACACAGAGCGCCATGGACTCAGTCAGATGTGATGTAGAGCAGGTGTGACGGAT <SEQ ID NO. 772 TBEV-8R; DNA; Artificial> ATCCGTCACACCTGCTCTACATCACATCTGACTGAGTCCATGGCGCTCTGTGTGTGGTGTTGGCTCCCGTAT <SEQ ID NO. 773 TBEV-10F; DNA; Artificial> ATACGGGAGCCAACACCATTGACTTGGCCGTCTCTGACCCCTAGCACCCCTCGCAGAGCAGGTGTGACGGAT <SEQ ID NO. 774 TBEV-10R; DNA; Artificial> ATCCGTCACACCTGCTCTGCGAGGGGTGCTAGGGGTCAGAGACGGCCAAGTCAATGGTGTTGGCTCCCGTAT 

I claim:
 1. A DNA ligand sequence consisting of a nucleic acid sequence SEQ ID NO.
 746. 2. A composition comprising the DNA ligand sequence of claim
 1. 